Evidence map›Paper›PMID 31935815›Full record

ArticleInternational journal of molecular sciences2020

Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway.

Charng-Cherng Chyau, Hsueh-Fang Wang, Wen-Juan Zhang, Chin-Chu Chen, Shiau-Huei Huang, Chun-Chao Chang, Robert Y Peng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 163 citations in OpenAlex.

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  18. Nutrients · 2025
    Article
  19. Article
  20. Comparative Efficacy ofAntioxidants (Basel, Switzerland) · 2025
    Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Charng-Cherng ChyauResearch Institute of Biotechnology, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung City 43302, Taiwan.ORCID 0000-0001-6801-5573
Hsueh-Fang WangInstitute of Biomedical Nutrition, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung City 43302, Taiwan.
Wen-Juan ZhangInstitute of Biomedical Nutrition, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung City 43302, Taiwan.
Chin-Chu ChenGrape King Biotechnology Center, 60, Sec 3, Longgang Rd., Chung-Li City, Taoyuan County 320, Taiwan.
Shiau-Huei HuangResearch Institute of Biotechnology, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung City 43302, Taiwan.
Chun-Chao ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11301, Taiwan.
Robert Y PengResearch Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei 11301, Taiwan.
Hungkuang University · TWGrape King (Taiwan) · TWTaipei Medical University · TWTaipei Medical University Hospital · TW

Funding

the Ministry of Science and Technology of the Republic of China MOST 107-2320-B-241-004-
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) and -steatohepatitis (NASH) imply a state of excessive fat built-up in livers with/or without inflammation and have led to serious medical concerns in recent years. Antrodan (Ant), a purified β-glucan from

Indexed as

Administration, OralAMP-Activated Protein Kinase KinasesAnimalsAntrodiaDiet, High-FatFructoseMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseasePlant ExtractsPPAR gammaProtein KinasesSignal TransductionSirtuin 1Sterol Regulatory Element Binding Protein 1AMP-Activated Protein Kinase KinasesFructosePlant ExtractsPPAR gammaProtein KinasesSirt1 protein, mouseSirtuin 1Srebf1 protein, mouseSterol Regulatory Element Binding Protein 1AntrodanAntrodia cinnamomeahepatoprotectivehigh-fat-high-fructose dietnon-alcoholic fatty liver disease (NAFLD), insulinorlistat

Identifiers

PMID31935815
PMCPMC6981486
OpenAlexW2998319093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.