ReviewIET nanobiotechnology2020
Toxicity of copper oxide nanoparticles: a review study.
Review in IET nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed.
- Evaluation of the antibacterial effect of titanium dioxide nanoparticles combined with acrylic laminates for functional orthodontic appliances: a randomized controlled clinical trial.BMC oral health · 2024Trial
- Centrifugally spun ZnO fibers: synthesis and antibacterial activity againstRSC advances · 2026Article
- Sargassum latifolium-mediated Se/CuO/MgO/ZnO nanocomposite enhances salt tolerance in Phaseolus vulgaris and exhibits antibacterial and antioxidant activities.Scientific reports · 2026Article
- Green Hydrothermal Synthesis of CuO-NPs and CuO-NPs@Alhagi Maurorum for Combating Multidrug Resistant Bacterial Infections.Biological trace element research · 2026Article
- Copper oxide nanoparticles: from EU-regulatory landscape and mechanistic toxicity towards a cuproptosis-linked adverse outcome pathway.Archives of toxicology · 2026Review
- Evaluation of the Effect of Copper Sulfate Exposure on Organs in Juvenile Rats.International journal of molecular sciences · 2026Article
- Metal Oxide Doping Modulates the Performances of Copper Oxide Nanoparticular Biocides.Nanomaterials (Basel, Switzerland) · 2026Article
- Visible-light-responsive FeRSC advances · 2026Article
- Sonochemically synthesized CuO-NPs: individual and synergistic toxicity assessment with sodium arsenite in adult zebrafish.RSC advances · 2026Article
- Ambivalent Copper: Mechanistically Distinct Immune Effects Driving Innovation in Cancer Nanomedicine.Pharmaceutics · 2026Review
- Green synthesis of CuO nanoparticles using thyme extract and their application as cephalexin carriers againstNanoscale advances · 2026Article
- Biogenic nanoparticles: overview of challenges in production, characterization and use.Frontiers in chemistry · 2026Review
- Pulmonary Exposure to Copper Oxide Nanoparticles Induces Systemic Inflammation, Oxidative Stress, and Prothrombotic Responses in BALB/c Mice.International journal of nanomedicine · 2026Article
- Equal nano-characteristics, unequal harm: the chemical composition of noble metal nanoparticles as the main factor of cytotoxicity.Frontiers in toxicology · 2026Article
- Article
- A Comprehensive Review on Copper Oxide Nanoparticles: Physicochemical Parameters, Pharmacological Potential and Pathophysiological Effects.International journal of nanomedicine · 2026Review
- Nephrotoxicity Evaluation of Green and Chemically Synthesized Copper Oxide Nanoparticles in Rats: A Biochemical and Genotoxic Approach.Current pharmaceutical design · 2026Article
- Impact of particle size and surface modifications on the neurotoxic potential of copper oxide nanoparticles.Scientific reports · 2025Article
- Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization.Annals of medicine · 2025Review
- Green Synthesized Copper-Oxide Nanoparticles Exhibit Antifungal Activity AgainstAntibiotics (Basel, Switzerland) · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper oxide nanoparticles (CuO NPs) use has exponentially increased in various applications (such as industrial catalyst, gas sensors, electronic materials, biomedicines, environmental remediation) due to their flexible properties, i.e. large surface area to volume ratio. These broad applications, however, have increased human exposure and thus the potential risk related to their short- and long-term toxicity. Their release in environment has drawn considerable attention which has become an eminent area of research and development. To understand the toxicological impact of CuO NPs, this review summarises the in-vitro and in-vivo toxicity of CuO NPs subjected to species (bacterial, algae, fish, rats, human cell lines) used for toxicological hazard assessment. The key factors that influence the toxicity of CuO NPs such as particle shape, size, surface functionalisation, time-dose interaction and animal and cell models are elaborated. The literature evidences that the CuO NPs exposure to the living systems results in reactive oxygen species generation, oxidative stress, inflammation, cytotoxicity, genotoxicity and immunotoxicity. However, the physio-chemical characteristics of CuO NPs, concentration, mode of exposure, animal model and assessment characteristics are the main perspectives that define toxicology of CuO NPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.