Evidence map›Paper›PMID 31935636›Full record

ArticleNeoplasia (New York, N.Y.)2020

Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer.

Alexandra M Kane, Lochlan J Fennell, Cheng Liu, Jennifer Borowsky, Diane M McKeone, Catherine E Bond, Stephen Kazakoff, Ann-Marie Patch, Lambros T Koufariotis, John Pearson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Gut · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. BRAFOncogene · 2020
    Article
  11. Cancers · 2020
    Article
  12. MLH1, BRAF and p53 - searching for significant markers to predict evolution towards adenocarcinoma in colonic sessile serrated lesions.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alexandra M KaneQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia; Conjoint Internal Medicine Laboratory, Pathology Queensland, Queensland Health, Brisbane, Queensland, Australia. Electronic address: Alexandra.Kane@qimrberghofer.edu.au.
Lochlan J FennellQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia.
Cheng LiuQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia; Envoi Specialist Pathologists, Brisbane, Queensland, Australia.
Jennifer BorowskyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia.
Diane M McKeoneQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Catherine E BondQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stephen KazakoffQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ann-Marie PatchQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lambros T KoufariotisQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
John PearsonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nicola WaddellQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Barbara A LeggettQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia; The Royal Brisbane and Women's Hospital, Queensland Health, Brisbane, Queensland, Australia.
Vicki L J WhitehallQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; The University of Queensland, Brisbane, Queensland, Australia; Conjoint Internal Medicine Laboratory, Pathology Queensland, Queensland Health, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAF

Indexed as

Animalsbeta CateninColorectal NeoplasmsCpG IslandsDisease Models, AnimalDNA MethylationExome SequencingHumansMiceMicrosatellite InstabilityMicrosatellite RepeatsMutationProto-Oncogene Proteins B-rafTransforming Growth Factor betaWnt Signaling Pathwaybeta CateninBraf protein, mouseCTNNB1 protein, mouseProto-Oncogene Proteins B-rafTransforming Growth Factor betaBRAFColorectal cancerMicrosatelliteTGF-βWNT

Identifiers

PMID31935636
PMCPMC6961716
OpenAlexW3000322084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.