ReviewCurrent opinion in chemical biology2020
Emerging strategies for expanding the toolbox of enzymes in biocatalysis.
Review in Current opinion in chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Lipase-Catalyzed Pathways to the Synthesis of Pharmacologically Active Amides.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Conformational Dynamics and Catalytic Backups in a Hyper-thermostable Engineered Archaeal Protein Tyrosine Phosphatase.JACS Au · 2026Article
- Emerging Applications of Thiol-Based Catalysts in Hydrogen Atom Transfer Reactions: A Comprehensive Review.Molecules (Basel, Switzerland) · 2025Review
- Computational Studies of Enzymes for C-F Bond Degradation and Functionalization.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Review
- Current status and emerging frontiers in enzyme engineering: An industrial perspective.Heliyon · 2024Review
- Enzymatic Synthesis of Austroeupatol Esters with Enhanced Antiprotozoal Activity.ACS medicinal chemistry letters · 2024Article
- From Ground-State to Excited-State Activation Modes: Flavin-Dependent "Ene"-Reductases Catalyzed Non-natural Radical Reactions.Accounts of chemical research · 2024Review
- Continuous flow synthesis enabling reaction discovery.Chemical science · 2024Review
- Remote stereocontrol with azaarenes via enzymatic hydrogen atom transfer.Nature chemistry · 2024Article
- Recent Developments and Applications of Biocatalytic and Chemoenzymatic Synthesis for the Generation of Diverse Classes of Drugs.Current pharmaceutical biotechnology · 2024Article
- Protein Hydrolysate from Underutilized Legumes: Unleashing the Potential for Future Functional Foods.Preventive nutrition and food science · 2023Review
- Analyzing Current Trends and Possible Strategies to Improve Sucrose Isomerases' Thermostability.International journal of molecular sciences · 2023Review
- A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases.Nature communications · 2023Article
- Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis.Science (New York, N.Y.) · 2023Article
- Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysis.Nature catalysis · 2023Article
- Photocatalytic Regeneration of a Nicotinamide Adenine Nucleotide Mimic with Water-Soluble Iridium(III) Complexes.Inorganic chemistry · 2023Article
- Review
- Lipase-Catalyzed Synthesis and Biological Evaluation ofACS medicinal chemistry letters · 2023Article
- Photoexcited Enzymes for Asymmetric CspAngewandte Chemie (International ed. in English) · 2022Review
- New Additions to the Arsenal of Biocatalysts for Noncanonical Amino Acid Synthesis.Current opinion in green and sustainable chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Expanding the repertoire of reactions available to enzymes is an enduring challenge in biocatalysis. Owing to the synthetic versatility of transition metals, metalloenzymes have been favored targets for achieving new catalytic functions. Although less well explored, enzymes lacking metal centers can also be effective catalysts for non-natural reactions, providing access to reaction modalities that compliment those available to metals. By understanding how these activation modes can reveal new functions, strategies can be developed to access novel biocatalytic reactions. This review will cover discoveries in the last two years which access catalytic reactions that go beyond the native repertoire of metal-free biocatalysts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.