SynthesisBlood advances2020
A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
What it found
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry.Blood cancer discovery · 2026Article
- Deciphering the genetic underlying causes of sex differences in multiple myeloma incidence and mortality.HGG advances · 2026Article
- Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.Translational oncology · 2026Review
- IL-6-driven POU2AF1 and ELL2 are key regulators of multiple myeloma-distinct transcriptional and splicing programs.Blood advances · 2026Article
- Review
- Social Determinants of Health Associated with Multiple Myeloma Incidence and Survival among a Low-Income Cohort in the Southeastern U.S.medRxiv : the preprint server for health sciences · 2026Article
- Monoclonal Gammopathies in Africa.Clinical lymphoma, myeloma & leukemia · 2025Review
- Polygenic Risk, Agent Orange Exposure, and Lymphoid Neoplasms in the Veterans Affairs Million Veteran Program.JAMA network open · 2025Article
- Racial Health Disparity and Risk of Multiple Myeloma: Implications for Energy Balance Interventions.Cancer prevention research (Philadelphia, Pa.) · 2025Review
- Addressing Health Disparities in Hematologic Malignancies: from Genes to Outreach.Blood cancer discovery · 2025Review
- FaMMily Affairs: Dissecting inherited contributions to multiple myeloma risk.Seminars in hematology · 2025Review
- Incidence and trends of multiple myeloma (MM) in Brazil - 1988-2020.Ecancermedicalscience · 2025Article
- Multiple myeloma.Nature reviews. Disease primers · 2024Review
- Addressing the disparities: the approach to the African American patient with multiple myeloma.Blood cancer journal · 2023Review
- Exome-wide screening identifies novel rare risk variants for bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Differences in the cytogenetic underpinnings of AL amyloidosis among African Americans and Caucasian Americans.Blood cancer journal · 2022Article
- Review
- Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.American journal of human genetics · 2021Article
- Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.American journal of human genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
70 authors at 20 institutions in 1 country.
Zhaohui DuCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Niels WeinholdMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Gregory Chi SongDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Kristin A RandDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
David J Van Den BergCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Amie E HwangDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Xin ShengCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Victor HomDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Sikander AilawadhiDivision of Hematology-Oncology, Mayo Clinic, Jacksonville, FL.
Ajay K NookaWinship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.
Seema SinghalDivision of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Karen PawlishCancer Epidemiology Services, Epidemiology, Environmental and Occupational Health Division, New Jersey Department of Health, Trenton, NJ.
Edward S PetersDepartment of Epidemiology, Louisiana State University School of Public Health, New Orleans, LA.
Cathryn BockKarmanos Cancer Center, Wayne State University, Detroit, MI.
Ann MohrbacherDivision of Hematology, Department of Medicine, University of Southern California, Los Angeles, CA.
Alexander StramDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Sonja I BerndtDivision of Cancer Genetics and Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
Victoria L StevensAmerican Cancer Society, Atlanta, GA.
Rick KittlesCity of Hope National Medical Center, Duarte, CA.
Phyllis J GoodmanThe Southwest Oncology Group Statistical Center, Seattle, WA.
W Ryan DiverAmerican Cancer Society, Atlanta, GA.
Anselm HennisDepartment of Preventive Medicine, Stony Brook University, Stony Brook, NY.
Barbara NemesureDepartment of Preventive Medicine, Stony Brook University, Stony Brook, NY.
Eric A KleinCleveland Clinic Foundation, Cleveland, OH.
Benjamin A RybickiHenry Ford Hospital, Detroit, MI.
Janet L StanfordFred Hutchinson Cancer Center, Seattle, WA.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Lisa SignorelloDivision of Cancer Genetics and Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Esther M JohnDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA.
Leslie BernsteinCity of Hope National Medical Center, Duarte, CA.
Antoinette M StroupCancer Epidemiology Services, Epidemiology, Environmental and Occupational Health Division, New Jersey Department of Health, Trenton, NJ.
Owen W StephensMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Maurizio ZangariMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Frits Van RheeMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR.
Andrew OlshanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Jennifer J HuDepartment of Public Health Sciences, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
Regina ZieglerDivision of Cancer Genetics and Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Sarah J NyanteDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Sue Ann InglesDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Michael F PressDepartment of Pathology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
John David CarptenCenter for Translational Genomics, Department of Translational Genomics, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Stephen J ChanockDivision of Cancer Genetics and Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Jayesh MehtaDivision of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Graham A ColditzDivision of Oncology, Washington University School of Medicine, Saint Louis, MO.
Jeffrey WolfDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Thomas G MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Michael TomassonDivision of Hematology, Oncology and Bone Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, IA.
Mark A FialaDivision of Oncology, Washington University School of Medicine, Saint Louis, MO.
Howard TerebeloProvidence Hospital, Southfield, MI.
Nalini JanakiramanDivision of Hematology-Oncology, Henry Ford Hospital, Detroit, MI.
Laurence KolonelUniversity of Hawaii Cancer Center, Honolulu, HI.
Kenneth C AndersonJ. Lipper Cancer Center for Multiple Myeloma, Dana-Farber Cancer Institute, Harvard University, Boston, MA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI.
Daniel AuclairMultiple Myeloma Research Foundation, Norwalk, CT.
Brian C-H ChiuDepartment of Public Health Sciences, University of Chicago, Chicago, IL.
Elad ZivDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Daniel StramDepartment of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Ravi VijDivision of Oncology, Washington University School of Medicine, Saint Louis, MO.
Leon Bernal-MizrachiGrady Memorial Hospital, Emory University, Atlanta, GA.
Gareth J MorganMyeloma Center, Perlmutter Cancer Center, New York University, New York, NY.
Jeffrey A ZonderKarmanos Cancer Center, Wayne State University, Detroit, MI.
Carol Ann HuffSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD; and.
Sagar LonialWinship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.
Robert Z OrlowskiDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX.
David V ContiCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Wendy CozenCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
University of Southern California · USNational Institutes of Health · USUniversity of Arkansas for Medical Sciences · USUniversity of California, San Francisco · USWashington University in St. Louis · USAmerican Cancer Society · USCity Of Hope National Medical Center · USEmory University · USHenry Ford Hospital · USNorthwestern University · USStony Brook University · USUniversity of Hawaiʻi at Mānoa · USUniversity of North Carolina at Chapel Hill · USVanderbilt University Medical Center · USWayne State University · USCancer Research And Biostatistics · USChicago Department of Public Health · USCleveland Clinic · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MSouthern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0MTrageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C., MUNSHI, NIKHIL C. · 2003 to 2023
$45.0MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTargeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MMultidisciplinary Studies of LymphomaZIACP010170 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MORTON, LINDSAY · 2009 to 2025
$10.7MResearch Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6MGenome Wide Admixture Scan for Multiple Myeloma in African AmericansR01CA134786 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COZEN, WENDY, HAIMAN, CHRISTOPHER ALAN · 2010 to 2015
$6.4MNCCDPHP CDC HHS U58 DP000807NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA014089NCI NIH HHS P50 CA100707NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA084979NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA134786NCI NIH HHS R21 CA191896NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA182883NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UG1 CA233163NCI NIH HHS UM1 CA182883NICHD NIH HHS P2C HD050924NIEHS NIH HHS P30 ES027792
Abstract
Persons of African ancestry (AA) have a twofold higher risk for multiple myeloma (MM) compared with persons of European ancestry (EA). Genome-wide association studies (GWASs) support a genetic contribution to MM etiology in individuals of EA. Little is known about genetic risk factors for MM in individuals of AA. We performed a meta-analysis of 2 GWASs of MM in 1813 cases and 8871 controls and conducted an admixture mapping scan to identify risk alleles. We fine-mapped the 23 known susceptibility loci to find markers that could better capture MM risk in individuals of AA and constructed a polygenic risk score (PRS) to assess the aggregated effect of known MM risk alleles. In GWAS meta-analysis, we identified 2 suggestive novel loci located at 9p24.3 and 9p13.1 at P < 1 × 10-6; however, no genome-wide significant association was noted. In admixture mapping, we observed a genome-wide significant inverse association between local AA at 2p24.1-23.1 and MM risk in AA individuals. Of the 23 known EA risk variants, 20 showed directional consistency, and 9 replicated at P < .05 in AA individuals. In 8 regions, we identified markers that better capture MM risk in persons with AA. AA individuals with a PRS in the top 10% had a 1.82-fold (95% confidence interval, 1.56-2.11) increased MM risk compared with those with average risk (25%-75%). The strongest functional association was between the risk allele for variant rs56219066 at 5q15 and lower ELL2 expression (P = 5.1 × 10-12). Our study shows that common genetic variation contributes to MM risk in individuals with AA.
Indexed as
Genome-Wide Association StudyMultiple MyelomaFemaleGenetic LociGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideTranscriptional Elongation FactorsELL2 protein, humanTranscriptional Elongation Factors
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