Evidence map›Paper›PMID 31935111›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Progesterone and estrogen regulate NALCN expression in human myometrial smooth muscle cells.

Chinwendu Amazu, Xiaofeng Ma, Clara Henkes, Juan J Ferreira, Celia M Santi, Sarah K England

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Article
  9. Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chinwendu AmazuDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.ORCID 0000-0003-2203-3658
Xiaofeng MaDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.
Clara HenkesDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.
Juan J FerreiraDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.
Celia M SantiDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.
Sarah K EnglandDepartment of Obstetrics Gynecology, Washington University in St. Louis, School of Medicine, St. Louis, Missouri.
Washington University in St. Louis · US

Funding

A NOVEL MOLECULAR MECHANISM FOR STIMULATING UTERINE CONTRACTILITY BY OXYTOCINR01HD088097 · NICHD · WASHINGTON UNIVERSITY · PI Sarah K. England, Celia M Santi · 2016 to 2026
$4.1M
Signaling Mechanisms in Myometrial Cells that Modulate Na+ Leak Channel Non-Selective (NALCN) during Pregnancy and LaborF30HD095591 · NICHD · WASHINGTON UNIVERSITY · PI AMAZU, CHINWENDU · 2018 to 2021
$156k
NICHD NIH HHS F30 HD095591NICHD NIH HHS R01 HD088097
6 · The paper itself

Abstract

During pregnancy, the uterus transitions from a quiescent state to an excitable, highly contractile state to deliver the fetus. Two important contributors essential for this transition are hormones and ion channels, both of which modulate myometrial smooth muscle cell (MSMC) excitability. Recently, the sodium (Na

Indexed as

AdultCell LineEstradiolFemaleHumansIon ChannelsMembrane ProteinsMutationMyocytes, Smooth MuscleMyometriumPregnancyProgesteroneResponse ElementsRNA, MessengerEstradiolIon ChannelsMembrane ProteinsNALCN protein, humanProgesteroneRNA, Messengerestrogenion channelmyometrial smooth muscle cellprogesteroneuterus

Identifiers

PMID31935111
PMCPMC7191408
OpenAlexW2999327912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.