ArticleeLife2020
State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- PTSD subtypes and their underlying neural biomarkers: a systematic review.Psychological medicine · 2025Pooled it
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Article
- Diverse Firing Profiles ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dreaming conundrum.Journal of sleep research · 2025Review
- The futuristic manifolds of REM sleep.Journal of sleep research · 2025Review
- Pupil size reveals arousal level fluctuations in human sleep.Nature communications · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Comparative analysis of spike-sorters in large-scale brainstem recordings.bioRxiv : the preprint server for biology · 2024Article
- Fiber photometry-based investigation of brain function and dysfunction.Neurophotonics · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Chemogenetic activation of astrocytes modulates sleep-wakefulness states in a brain region-dependent manner.Sleep advances : a journal of the Sleep Research Society · 2024Article
- The Ponto-Geniculo-Occipital (PGO) Waves in Dreaming: An Overview.Brain sciences · 2023Review
- Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep.Sleep · 2023Article
- The neurophysiologic landscape of the sleep onset: a systematic review.Journal of thoracic disease · 2023Review
- A medullary hub for controlling REM sleep and pontine waves.Nature communications · 2023Article
- The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex.Nature communications · 2022Article
- Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Forebrain control of breathing: Anatomy and potential functions.Frontiers in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The brainstem plays a crucial role in sleep-wake regulation. However, the ensemble dynamics underlying sleep regulation remain poorly understood. Here, we show slow, state-predictive brainstem ensemble dynamics and state-dependent interactions between the brainstem and the hippocampus in mice. On a timescale of seconds to minutes, brainstem populations can predict pupil dilation and vigilance states and exhibit longer prediction power than hippocampal CA1 neurons. On a timescale of sub-seconds, pontine waves (P-waves) are accompanied by synchronous firing of brainstem neurons during both rapid eye movement (REM) and non-REM (NREM) sleep. Crucially, P-waves functionally interact with CA1 activity in a state-dependent manner: during NREM sleep, hippocampal sharp wave-ripples (SWRs) precede P-waves. On the other hand, P-waves during REM sleep are phase-locked with ongoing theta oscillations and are followed by burst firing of CA1 neurons. This state-dependent global coordination between the brainstem and hippocampus implicates distinct functional roles of sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.