Evidence map›Paper›PMID 31934860›Full record

ArticleeLife2020

Imp/IGF2BP levels modulate individual neural stem cell growth and division through

Tamsin J Samuels, Aino I Järvelin, David Ish-Horowicz, Ilan Davis

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  8. Altering cell size asymmetry inbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tamsin J SamuelsDepartment of Biochemistry, The University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4670-1139
Aino I JärvelinDepartment of Biochemistry, The University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-1225-4396
David Ish-HorowiczDepartment of Biochemistry, The University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5684-7129
Ilan DavisDepartment of Biochemistry, The University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5385-3053
University of Oxford · GB

Funding

Wellcome 209412/Z/17/ZWellcome TrustWellcome Trust 096144/Z/17/ZWellcome Trust 105363/Z/14/Z
6 · The paper itself

Abstract

The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals. However, the cell-intrinsic mechanisms that control the distinctive proliferation rates of individual neural stem cells are unknown. Here, we show that the size and division rates of

Indexed as

RNA StabilityAnimalsBrainCell DifferentiationCell ProliferationDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Situ Hybridization, FluorescenceLarvaMaleMushroom BodiesNeural Stem CellsProtein BindingDNA-Binding ProteinsDrosophila ProteinsGreen Fluorescent ProteinsImp protein, DrosophilaMyc protein, DrosophilaRNA-Binding ProteinsRNA, MessengerTranscription Factorsdevelopmental biologyD. melanogastermRNA stabilitymycneural stem cellneuroblastneuroscienceRNA-binding proteinsingle molecule fish

Identifiers

PMID31934860
PMCPMC7025822
OpenAlexW2999282536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.