Evidence map›Paper›PMID 31934750›Full record

ArticleAnalytical chemistry2020

Injection Molded Microfluidics for Establishing High-Density Single Cell Arrays in an Open Hydrogel Format.

Ying Li, Jeffrey D Motschman, Sean T Kelly, Benjamin B Yellen

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  7. Metabolomics: A useful tool for ischemic stroke research.Journal of pharmaceutical analysis · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ying LiDepartment of Mechanical Engineering and Materials Science , Duke University , Durham , North Carolina 27708 , United States.
Jeffrey D MotschmanDepartment of Mechanical Engineering and Materials Science , Duke University , Durham , North Carolina 27708 , United States.
Sean T KellyDepartment of Mechanical Engineering and Materials Science , Duke University , Durham , North Carolina 27708 , United States.
Benjamin B YellenDepartment of Mechanical Engineering and Materials Science , Duke University , Durham , North Carolina 27708 , United States.ORCID 0000-0002-8669-6752
Duke University · US

Funding

University Training Program in Biomolecular & Tissue EngineeringT32GM008555 · NIGMS · DUKE UNIVERSITY · PI GERSBACH, CHARLES A. · 1994 to 2021
$8.1M
University Training Program in Biomolecular and Tissue EngineeringT32GM144291 · NIGMS · DUKE UNIVERSITY · PI Charles A. Gersbach, Tatiana Segura · 2022 to 2026
$2.6M
Magnetically directed single cell transcriptome analysis in HIV latencyR01GM123542 · NIGMS · DUKE UNIVERSITY · PI MURDOCH, DAVID MARTIN · 2016 to 2018
$1.7M
Magnetically directed single cell transcriptome analysis in HIV latencyR01AI150465 · NIAID · DUKE UNIVERSITY · PI MURDOCH, DAVID MARTIN · 2019 to 2020
$1.1M
Image-Seq: A high-density microfluidic trap array for single cell transcriptome analysis coupled with image based phenotypingR21GM131279 · NIGMS · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2018 to 2019
$432k
NIAID NIH HHS R01 AI150465NIGMS NIH HHS R01 GM123542NIGMS NIH HHS R21 GM131279NIGMS NIH HHS T32 GM008555NIGMS NIH HHS T32 GM144291
6 · The paper itself

Abstract

Here, we develop an injection molded microfluidic approach for single cell analysis by making use of (1) rapidly curing injectable hydrogels, (2) a high density microfluidic weir trap array, and (3) reversibly bonded PDMS lids that are strong enough to withstand the injection molding process, but which can be peeled off after the hydrogel sets. This approach allows for single cell patterns to be created with densities exceeding 40 cells per mm

Indexed as

Microfluidic Analytical TechniquesSingle-Cell AnalysisAcrylatesAutomationHL-60 CellsHumansHydrogelsK562 CellsOptical ImagingPolyethylene GlycolsTumor Cells, CulturedAcrylatesacrylic acidHydrogelsPolyethylene Glycols

Identifiers

PMID31934750
PMCPMC7295173
OpenAlexW2999086771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.