Evidence map›Paper›PMID 31934610›Full record

ArticleNPJ Parkinson's disease2020

Dementia in long-term Parkinson's disease patients: a multicentre retrospective study.

Jennifer Y Y Szeto, Courtney C Walton, Alexandra Rizos, Pablo Martinez-Martin, Glenda M Halliday, Sharon L Naismith, K Ray Chaudhuri, Simon J G Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer Y Y Szeto1Parkinson's Disease Research Clinic, Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW Australia.
Courtney C Walton1Parkinson's Disease Research Clinic, Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW Australia.
Alexandra Rizos2Parkinson Foundation International Centre of Excellence, King's College Hospital and Kings College London, London, UK.
Pablo Martinez-Martin5Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.ORCID 0000-0003-0837-5280
Glenda M Halliday6Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW Australia.ORCID 0000-0003-0422-8398
Sharon L Naismith1Parkinson's Disease Research Clinic, Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW Australia.
K Ray Chaudhuri2Parkinson Foundation International Centre of Excellence, King's College Hospital and Kings College London, London, UK.
Simon J G Lewis1Parkinson's Disease Research Clinic, Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW Australia.ORCID 0000-0002-4093-7071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While several studies have investigated the clinical progression of cognitive decline in Parkinson's disease (PD) patients, there has been a paucity of data on specifically evaluating PD patients with a disease duration of over 20 years. This study retrospectively investigated the frequency of dementia in PD (PDD) patients with a disease duration of over 20 years assessed in research clinics across the UK and Australia. Data from 2327 PD patients meeting the United Kingdom Parkinson's Disease Society Brain Bank Criteria was pooled. A diagnosis of probable PDD was made according to the Movement Disorder Society Level 1 criteria. Thirty-six participants had a disease duration of at least 20 years. Of the 36 patients, only 7 (19%) were classified as probable PDD. Compared to PD patients without dementia, those with dementia had lower levels of educational attainment and exhibited more severe motor features. Additionally, 34 out of the 36 patients (94%) exhibited a non-tremor dominant phenotype. No significant differences in age, age onset, disease duration, dopaminergic medication use, and sex distribution were observed between PD patients with and without dementia. Findings from the present study suggest that the prevalence of dementia in long-term PD patients may be lower than anticipated and suggest that the trajectory of cognitive decline in PD patients can be different. These findings highlight the need to investigate factors that might affect the outcome of cognitive decline in long-term PD patients, which may lead to the determination of potential modulating factors in the development of dementia in these patients.

Indexed as

DementiaParkinson's disease

Identifiers

PMID31934610
PMCPMC6946687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.