Evidence map›Paper›PMID 31934312›Full record

ArticleMediterranean journal of hematology and infectious diseases2020

Chronic Graft-Versus-Host-Disease-Related Polymyositis: a 17-Months-Old Child with a Rare and Late Complication of Haematopoietic Stem Cell Transplantation.

Matteo Chinello, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Paola Tonin, Gaetano Vattemi, Valeria Guglielmi, Simone Cesaro

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Matteo ChinelloPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Rita BalterPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Massimiliano De BortoliPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Virginia VitalePediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Ada ZaccaronPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Elisa BonettiPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Paola ToninDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Italy.
Gaetano VattemiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Italy.
Valeria GuglielmiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Italy.
Simone CesaroPediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Azienda Ospedaliera Universitaria Integrata Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic graft versus host disease (cGVHD) occurs in 20-30% of paediatric patients receiving haemopoietic stem cell transplantation (HSCT). Neuromuscular disorders such as polymyositis are considered a rare and distinctive but non-diagnostic manifestation of cGVHD and, in the absence of other characteristic signs and symptoms, biopsy is highly recommended to exclude other causes. CASE REPORT: We report a case of a 17-months-old child affected by hemophagocytic lymphohistiocytosis who underwent a matched unrelated donor haematopoietic stem cell transplantation (HSCT). She developed severe cGVHD-related polymyositis that was successfully treated with high-dose steroid therapy, rituximab and sirolimus.

conclusionsThis is the first case of cGVHD-related-polymyositis described in a pediatric patient which was successfully treated with rituximab.

Indexed as

Chronic graft-versus-host-diseaseEmapalumabHemophagocytic LymphohistiocytosisMethylprednisolonePolymyositisRituximabSirolimus

Identifiers

PMID31934312
PMCPMC6951354
OpenAlexW2998046031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.