ArticleComputational and structural biotechnology journal2020
Causal inference for the effect of environmental chemicals on chronic kidney disease.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status.Ecotoxicology and environmental safety · 2025Article
- Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review.Toxics · 2025Review
- Environmental factors and chronic kidney disease: a case-control study.Scientific reports · 2024Article
- Early-life exposure to per- and polyfluoroalkyl substances: Analysis of levels, health risk and binding abilities to transport proteins.Eco-Environment & Health · 2024Article
- A State-of-the-Science Review of Interactions of Per- and Polyfluoroalkyl Substances (PFAS) with Renal Transporters in Health and Disease: Implications for Population Variability in PFAS Toxicokinetics.Environmental health perspectives · 2023Review
- Article
- Associations between PFAS occurrence and multimorbidity as observed in an electronic health record cohort.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Per- and polyfluoroalkyl substances and kidney function: Follow-up results from the Diabetes Prevention Program trial.Environment international · 2021Article
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.Environmental toxicology and chemistry · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impacts of environmental chemicals on the decline of kidney function have been suggested by a limited number of statistical and animal studies. Thus, those exposures may be modifiable risk factors for chronic kidney disease. Some of the chemicals, such as Perfluoroalkyl acid (PFA), are pervasive throughout our environment, determining their health effects is an important public health concern. In this study, we examined cross-sectional data from the 2009-2010 cycle of the National Health and Nutrition Examination Survey (NHANES) using a statistical causal inference method-generalized propensity score method, to determine the links between concentrations of several major environmental chemicals and kidney function measured by the estimated glomerular filtration rate (eGFR). Various generalized propensity score estimation methods including Hirano-Imbens, additive spline, and a generalized additive model were compared. Among the examined environmental chemicals, each of the statistical models used associated an increase in PFA concentration with a decline in eGFR. We conclude that PFA is a modifiable risk factor for chronic kidney disease and the statistical causal method produces credible results in estimating the effect of chemical exposures on a continuous measure of kidney functions with an observational dataset.
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