Evidence map›Paper›PMID 31934289›Full record

ArticleAmerican journal of translational research2019

Anti-GPC3 single-chain scFv antibody acts as an agent for radio-immunoimaging in diagnosing hepatocellular carcinoma.

Lili Guan, Wei Wu, Hua Pang, Dong Duan, Shaolin Li

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lili GuanDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
Wei WuThe Chongqing Key Laboratory of Toxicology and Drug Analysis, Chongqing Police College Chongqing, China.
Hua PangDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
Dong DuanDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
Shaolin LiDepartment of Radiology, Chongqing Medical University Chongqing, China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNChongqing Emergency Medical Center · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glypican-3 (GPC3) over-expresses in hepatocellular carcinoma (HCC), but not expresses or under-expresses in normal adult hepatocytes. Therefore, GPC3 acts as a potential target for diagnosis and treatment of HCC. This study aimed to conduct radio-immunoimaging using GPC3 as a target in order, and to explore its potential for diagnosing and treating HCC. Humanized single-chain antibody scFv for HCC was established using phage antibody library.

Indexed as

GPC3Hepatocellular carcinomaphage display technologyradio-immunoimagingsingle-chain antibody

Identifiers

PMID31934289
PMCPMC6943449
OpenAlexW3010199441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.