Evidence map›Paper›PMID 31934280›Full record

ArticleAmerican journal of translational research2019

Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine.

Bowen Yu, Bo Yuan, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Xiaohua Pei and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Tetrandrine Citrate Suppresses Breast CancerFrontiers in pharmacology · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Bowen YuDepartment of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Bo YuanDepartment of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Anna KiyomiDepartment of Drug Safety and Risk Management, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Hidetomo KikuchiLaboratory of Pharmacotherapy, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Hideki HayashiDepartment of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Xiaomei HuXiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, P. R. China.
Mari OkazakiLaboratory of Pharmacology, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Munetoshi SugiuraDepartment of Drug Safety and Risk Management, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Toshihiko HiranoDepartment of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Xiaohua PeiBeijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029, P. R. China.
Norio TakagiDepartment of Applied Biochemistry, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Tokyo University of Pharmacy and Life Sciences · JPJosai University · JPBeijing University of Chinese Medicine · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo provide novel insight into the development of new therapeutic strategies to combat breast cancer, differentiation-inducing activity of clinically achievable concentrations of arsenite (As

methodsDifferentiation induction of cancer cells was analyzed by flow cytometer. Alterations of genes related to differentiation, and proliferation of human normal peripheral blood mononuclear cells (PBMCs) were analyzed using western blotting and cell viability assay, respectively.

resultsExposure to Tetra alone or in combination with As

conclusionThe Erk signaling pathway may be crucially involved in the differentiation induction of breast cancer cells

Indexed as

Arsenitebreast cancer cellscombination therapydifferentiationtetrandrineTreg cells

Identifiers

PMID31934280
PMCPMC6943472
OpenAlexW3005383381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.