ArticleAmerican journal of translational research2019
MiRNA-130a-3p inhibits cell proliferation, migration, and TMZ resistance in glioblastoma by targeting Sp1.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- A thematic analysis of prognostic, diagnostic, and therapeutic of circulating miRNA biomarkers in bortezomib-resistant multiple myeloma.SAGE open medicine · 2025Review
- Research progress of drug resistance mechanism of temozolomide in the treatment of glioblastoma.Heliyon · 2024Review
- Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.Journal of cancer research and clinical oncology · 2023Article
- Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity.Journal of clinical medicine · 2023Article
- Low SP1 SUMOylation-dependent SNHG17 upregulation promotes drug resistance of gastric cancer through impairing hsa-miR-23b-3p-induced Notch2 inhibition.Cellular oncology (Dordrecht, Netherlands) · 2022Article
- Sp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma.Scientific reports · 2022Article
- Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis.Journal of cell communication and signaling · 2022Article
- MiR-130a-3p regulates neural stem cell differentiation in vitro by targeting Acsl4.Journal of cellular and molecular medicine · 2022Article
- MiR-526b-3p Inhibits the Resistance of Glioma Cells to Adriamycin by Targeting MAPRE1.Journal of oncology · 2022Article
- Midkine promotes glioblastoma progression via PI3K-Akt signaling.Cancer cell international · 2021Article
- circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis.BMC molecular and cell biology · 2021Article
- Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- Article
- miRNA-130a-3p/CPEB4 Axis Modulates Glioblastoma Growth and Progression.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specificity protein 1 (Sp1) is aberrantly expressed and involved in the development and metastasis of glioblastoma. In this study, we observed that the expression of Sp1 was upregulated while that of microRNA (miR)-130a-3p was downregulated in glioblastoma cell lines. Sp1 was validated as a target of miR-130a-3p; increased levels of miR-130a-3p inhibited the proliferation, migration, and temozolomide (TMZ) resistance of the glioblastoma cells. However, Sp1 overexpression compromised the inhibitory effects of miR-130a-3p. Our study elucidates the functional interaction between miR-130a-3p and Sp1 in the development and progression of glioblastoma, suggesting a potential therapeutic target for the disease.
Indexed as
Identifiers
31934277PMC6943444W3013584387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.