ArticleInternational journal of clinical and experimental pathology2019
Expression of ATP7A in esophageal squamous cell carcinoma (ESCC) and its clinical significance.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- ATP7A and LIAS promote lung adenocarcinoma progression through regulation of cuproptosis.Cancer cell international · 2026Article
- ATP7A as a prognostic biomarker and potential therapeutic target in gastric cancer.American journal of translational research · 2025Article
- Article
- The Impact of YRNAs on HNSCC and HPV Infection.Biomedicines · 2023Article
- Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A.Molecular oncology · 2021Article
- Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study investigated the expression of P-type copper transporting adenosine triphosphatase ATP7A in the tumor tissues of patients with advanced esophageal squamous cell carcinoma (ESCC), and analyzed its correlation to clinicopathologic features and prognosis of advanced ESCC patients.
methodsThe expression of ATP7A protein in 49 specimens of advanced ESCC patients who were treated with first line cisplatin-based chemotherapy without surgery or radiotherapy, was detected by immunohistochemistry. The correlation of ATP7A expression with clinicopathologic features and prognosis of advanced ESCC patients weas analyzed by SPSS 16.0 statistical software package.
resultsPositive ATP7A staining was observed in cytoplasm of ESCC cells in 44. of tumors (22 of 49 cases), but was not detected in adjacent stroma of tumor tissue. ATP7A expression status was correlated with response to histologic grade and cisplatin-based chemotherapy (
conclusionATP7A was positively expressed in the majority of advanced ESCC tissues. The expression level of ATP7A was an important factor affecting tumor tissue's histologic grade, the response to platinum-based chemotherapy and the prognosis of advanced ESCC patients. This indicates that ATP7A might be involved in the genesis and development of ESCC, and could be a resistance marker for platinum-based chemotherapy, and a prognostic factor for survival in patients with ESCC treated by Pt-based chemotherapy.
Indexed as
Identifiers
31934199PMC6949815W3026436849What OpenQuestion holds
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