ArticleInternational journal of clinical and experimental pathology2019
The clinicopathological significance and prognostic value of β-catenin Ser45-phosphorylation expression in esophageal squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.Cancers · 2022Article
- NRAGE Confers Radiation Resistance in 2D and 3D Cell Culture and Poor Outcome in Patients With Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.Science signaling · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Catenin is a multifunctional protein which plays a central role in physiological homeostasis, and it acts both as an adaptor protein for intracellular adhesion and a transcriptional co-regulator. As a pivotal component of the Wnt signaling pathway, the accumulation of β-catenin in the cytoplasm/nucleus leads to many diseases including cancer. The phosphorylation at Ser45 of β-catenin causes the degradation of β-catenin, which makes β-catenin at a very low level. It has been shown that phosphorylation at Ser45 of β-catenin is closely related to the occurrence and development of tumors. However, little is known about the exact role of β-catenin Ser45-phosphorylation in esophageal squamous cell carcinoma (ESCC). PURPOSE: The present study was aimed at exploring the role and the prognostic value of the expression of β-catenin Ser45-phosphorylation in ESCC.
methodsThe expression of phosphorylation at Ser45of β-catenin was detected by immunohistochemistry in 90 cases of ESCC and their corresponding adjacent nonneoplastic esophageal tissues (n = 90). We then evaluated the relationships among the expressions of phosphorylation at Ser45 of β-catenin, the clinicopathological parameters, and the prognoses of the ESCC patients.
resultsThe expression level of phosphorylation at Ser45 of β-catenin in ESCC was 65.6% (59/90), significantly lower than the expression level in nonneoplastic esophageal tissues, where it was 88.9% (80/90), (X
conclusionβ-catenin Ser45-phosphorylation may play an important role in the pathogenesis and development of ESCC and may provide clinically useful prognostic information.
Indexed as
Identifiers
31934197PMC6949858W3026704110What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.