ArticleInternational journal of clinical and experimental pathology2019
Clinicopathological significances of Feline sarcoma-related protein and β2-adrenoceptor expression in pancreatic ductal adenocarcinomas.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Breaking the ERK1/2 negative feedback loop: avoiding reactivation and acquisition of resistance by ERK1/2 to anti-cancer agents.Frontiers in oncology · 2026Review
- Fer-mediated activation of the Ras-MAPK signaling pathway drives the proliferation, migration, and invasion of endometrial carcinoma cells.Molecular and cellular biochemistry · 2024Article
- Fer governs mTORC1 regulating pathways and sustains viability of pancreatic ductal adenocarcinoma cells.Frontiers in oncology · 2024Article
- Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a high mortality, but biomarkers for its diagnosis, target therapy, and prognosis are not clinically available. MATERIALS AND
methodsIn the present study, Feline sarcoma-related protein (Fer) and ADRB2 protein expression was detected by immunohistochemistry. RESULTS AND DISCUSSION: Comparing with the peritumoral tissues, benign pancreatic tissues, and normal pancreatic tissues, Fer and ADRB2 protein was overexpressed in PDAC tumor tissues (P < 0.01). The percentage of patients with positive Fer and ADRB2 expression were significantly lower in PDAC without lymph node metastasis, without invasion to surrounding tissues and organs, and with low TNM stage (I/II stage) disease compared to PDAC patients with metastasis, invasion, and high TNM stage (III/IV) disease. PDAC patients with positive Fer or ADRB2 protein expression survived significantly shorter time than patients with negative Fer or ADRB2 protein expression (P = 0.000). Positive Fer and ADRB2 protein expression was an independent factor for poor prognosis of PDAC patients and ROC curve analysis showed that positive Fer and ADRB2 protein expression was sensitive and specific marker for the PDAC diagnosis. In conclusion, positive Fer and ADRB2 expression is associated with carcinogenesis of PDAC, disease progression, and poor prognosis of PDAC patients.
Indexed as
Identifiers
31934182PMC6949805W3014798027What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.