ArticleInternational journal of clinical and experimental pathology2019
Immunhistochemical expression of GLUT1 is associated with low grade and low stage of urinary bladder cancer.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- PIGT promotes cell growth, glycolysis, and metastasis in bladder cancer by modulating GLUT1 glycosylation and membrane trafficking.Journal of translational medicine · 2024Article
- Article
- The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy.Frontiers in immunology · 2023Review
- Current Development and Application of Anaerobic Glycolytic Enzymes in Urothelial Cancer.International journal of molecular sciences · 2021Review
- Long noncoding RNA PVT1 promotes tumor cell proliferation, invasion, migration and inhibits apoptosis in oral squamous cell carcinoma by regulating miR‑150‑5p/GLUT‑1.Oncology reports · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies described glucose transporter 1 (GLUT1) as a fundamental player in cancer metabolism, which can be employed as a prognostic biomarker that may help in new treatment strategy development. This study will describe the pattern of GLUT1 expression in urinary bladder cancer and try to associate it with tumor clinicopathologic factors. Standard immunohistochemistry (IHC) staining protocol was utilized to identify the location and expression pattern of GLUT1 in a panel of 128 urinary bladder carcinoma compared to 24 normal tissues using tissue microarrays. GLUT1 expression was found up-regulated significantly in cancer cases, and it was found in 111 (86.7%) urinary bladder cancers compared to 4 (16.6%) of control cases (P < 0.05). Positive GLUT1 immunohistochemical staining was significantly correlated with low grade, low stage, and non-muscularis propria invasive urinary bladder cancer cases (P < 0.05). Log-rank test and Kaplan Meier survival curves displayed significant poor survival in stage III and stage IV patients (P < 0.05); mean survival is lowest at 29.924 months in stage IV patients. Similarly, significantly better survival is observed in low-grade tumors (P < 0.05). Urinary bladder cancer showed increased GLUT1 expression compared to a control group. IHC staining of GLUT1 can be a supportive tool in predicting prognostic and survival estimates of urinary bladder tumors with specific clinical and morphologic characteristics.
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Identifiers
31934144PMC6949691W3026126755What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.