ArticleInternational journal of clinical and experimental pathology2019
Diesel exhaust particles induce toxicity to beta cells by suppressing miR-140-5p.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Resolving DNA Damage: Epigenetic Regulation of DNA Repair.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The toxicologic effects of diesel exhaust particles (DEPs) on lung cells and function have been heavily studied. However, it remains largely unknown how DEPs affect the function of pancreatic beta cells. In this study, wedemonstrated that DEP extract (DPE) exposure significantly reduces cell viability, insulin secretion, and ATP and GSH production of rat pancreatic beta cells. Also, DPEs induce the accumulation of ROS, p53 expression, and DNA damage in beta cells. In addition, the expression level of miR-140-5p was downregulated in beta cells following DPE exposure, and ectopic expression of miR-140-5p could partly attenuate the toxic effects of DPEs. Mechanistically, HDCA4 and HDCA7 were downstream targets of miR-140-5p. In conclusion, our findingsdemonstrate that DPE exposure impairs the normal functions of beta cells by downregulating miR-140-5p. Further studies are warranted to explore the toxic effects of circulating DEPs on the pancreas.
Indexed as
Identifiers
31934122PMC6949722W3012275640What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.