ArticleInternational journal of clinical and experimental pathology2019
Comparison of endothelial cell- and endothelial progenitor cell-derived exosomes in promoting vascular endothelial cell repair.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- From Cerebrovascular Injury to Vascular Cognitive Impairment and Dementia: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles.Biomedicines · 2026Review
- Exosomes: the future of acellular nanotherapeutics in regenerative vascularization.Frontiers in bioengineering and biotechnology · 2025Review
- Diverse-Origin Exosomes Therapeutic Strategies for Diabetic Wound Healing.International journal of nanomedicine · 2025Review
- HUVECs-derived exosomes increase neovascularization and decrease limb necrosis in hindlimb ischemia.Narra J · 2024Article
- Exosomes and microRNAs: insights into their roles in thermal-induced skin injury, wound healing and scarring.Molecular genetics and genomics : MGG · 2024Review
- Clinical applications of stem cell-derived exosomes.Signal transduction and targeted therapy · 2024Review
- Sirolimus-loaded exosomes as a promising vascular delivery system for the prevention of post-angioplasty restenosis.Drug delivery and translational research · 2024Article
- Elucidation of endothelial progenitor cell dysfunction in diabetes by RNA sequencing and constructing lncRNA-miRNA-mRNA competing endogenous RNA network.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Protective effects of endothelial progenitor cell microvesicles carrying miR‑98‑5p on angiotensin II‑induced rat kidney cell injury.Experimental and therapeutic medicine · 2022Article
- Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment.Stem cell research & therapy · 2022Review
- Protective effects of endothelial progenitor cell microvesicles on Ang II‑induced rat kidney cell injury.Molecular medicine reports · 2022Article
- Extracellular vesicles produced by human-induced pluripotent stem cell-derived endothelial cells can prevent arterial stenosis in mice via autophagy regulation.Frontiers in cardiovascular medicine · 2022Article
- Association of Gene Polymorphisms of Some Endothelial Factors with Stent Reendothelization after Elective Coronary Artery Revascularization.Bulletin of experimental biology and medicine · 2021Article
- Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia.International journal of molecular sciences · 2021Review
- Cardioprotective Roles of Endothelial Progenitor Cell-Derived Exosomes.Frontiers in cardiovascular medicine · 2021Review
- Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations.Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTimely endothelial repair after intervention-associated vascular injury is critical to prevent restenosis and thrombosis. Compared to living cell therapies, exosomes may be a better alternative. Thus, we aimed to compare the role of exosomes derived from human umbilical vein endothelial cells (HUVECs) versus those derived from endothelial progenitor cells (EPCs) in vascular endothelial repair. MATERIAL/
methodsExosomes secreted from HUVECs and EPCs were isolated and characterized respectively. In vitro, the effects of the two types of exosomes on migration and proliferation of endothelial cells were studied. In vivo, rats were systemically treated with the two exosome groups respectively after carotid artery endothelial injury induced by a balloon. The efficacy in promoting re-endothelialization was measured by Evans blue dye and histological examination.
resultsBoth types of exosomes, sized from 30 nm to 100 nm, had sphere-shaped or cupped morphology, and expressed CD63, CD9, and CD81; but the total yield of exosomes (particles/mL) based on number of cells, was 4.2 times higher from EPCs than HUVECs. Compared with control treatment, both exosome treated groups manifested significant enhancement of migration and proliferation in vitro and vascular recovery at an early stage in vivo. The two exosome-treated groups, however, did not statistically significantly differ.
conclusionIn conclusion, our results indicated that exosomes derived from HUVECs and EPCs had similar morphology, size distributions and characteristics, but those derived from EPCs were more abundant with comparable biologic activity. Therefore, EPCs may be a robust source of exosomes to promote vascular repair.
Indexed as
Identifiers
31934115PMC6949553W3005495156What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.