ArticleInternational journal of clinical and experimental pathology2019
Effect of autophagy on cardiomyocyte membrane Cx43 acute remodeling in rats with ischemia-reperfusion.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- The impact of the PI3K/AKT pathway on arrhythmia: mechanisms of action and therapeutic potential.Journal of molecular histology · 2026Review
- A Membrane-Targeting Aggregation-Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia/Reperfusion-Induced Cardiomyocyte Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia.Immunity, inflammation and disease · 2023Article
- Effects of ivabradine on ventricular electrophysiological remodeling after myocardial infarction in rats.Archives of medical science : AMS · 2023Article
- Autophagy and the hallmarks of aging.Ageing research reviews · 2021Review
- Modulation of Vascular Smooth Muscle Cell Multiplication, Apoptosis, and Inflammatory Damage by miR-21 in Coronary Heart Disease.Computational and mathematical methods in medicine · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the impact of autophagy on cardiomyocyte membrane connexin 43 (Cx43) expression, distribution, and phosphorylation in myocardial ischemia-reperfusion injury (MI/RI).
methodsTwenty-four male SD rats were randomly divided into a sham operation group, a chloroquine (CQ) + sham operation group, an I/R group, and a CQ + I/R group. The MI/RI model was established by reversible ligation of the left anterior descending coronary artery to induce ischemia for 30 min and reperfusion for 2 h. The left ventricular infarct size was measured by TTC (2,3,5-triphenyltetrazolium chloride) and Evans blue double staining. Cardiac troponin I (cTnI) content was detected by automatic biochemical analyzer. Autophagy related gene Beclin1, Cx43, and p-Cx43 protein expressions were tested by western blot. Cx43 and p-Cx43 distributions in ventricular myocardium were observed by immunofluorescence analysis.
resultsCompared with the I/R group, the left ventricular infarct size, serum cTnI content, reperfusion arrhythmia severity, and in vivo induced ventricular fibrillation threshold, and Beclin-1 protein expression were significantly reduced in CQ + I/R group (P < 0.05). Compared with the SH group, Beclin-1 protein expression was significantly enhanced, while Cx43 and p-Cx43 levels were obviously downregulated in the I/R group. Beclin-1 protein declined, whereas Cx43 and p-Cx43 levels enhanced in CQ + I/R group compared with the I/R group.
conclusionAutophagy may reduce myocardial ischemia-reperfusion injury and malignant arrhythmia by improving the acute remodeling of myocardial cell membrane Cx43.
Indexed as
Identifiers
31934092PMC6949570W3003198626What OpenQuestion holds
Registered trials
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