ArticleInternational journal of clinical and experimental pathology2019
Long non-coding RNA NKILA inhibits proliferation and migration of lung cancer via IL-11/STAT3 signaling.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Expression Level and Clinical Significance of NKILA in Human Cancers: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis.Molecular medicine reports · 2026Article
- LncRNA NKILA as a key regulator in cancer pathogenesis: insights into its mechanisms and clinical implications.Cancer cell international · 2026Review
- Long non-coding RNAs and signaling networks in non-small cell lung cancer: mechanistic insights into tumor pathogenesis.Cancer gene therapy · 2025Review
- Unraveling LncRNAs: the future of lung cancer treatment.Journal of the Egyptian National Cancer Institute · 2025Review
- IL-6-induced long noncoding RNA MIR3142HG promotes tumorigenesis by interacting with thioredoxin-1 and STAT3 in human colorectal cancer.Cellular & molecular biology letters · 2025Article
- The regulatory role and therapeutic potential of long non-coding RNA in non-small cell lung cancer.Journal of Cancer · 2025Review
- Identification and Validation of 7-lncRNA Signature of Epigenetic Disorders by Comprehensive Epigenetic Analysis.Disease markers · 2022Article
- Long non-coding RNA NKILA regulates expression of HSP90α, NF-κB and β-catenin proteins in the MCF-7 breast cancer cell line.Molecular biology reports · 2021Article
- Multivariate gene expression-based survival predictor model in esophageal adenocarcinoma.Thoracic cancer · 2020Article
- LncRNAs in Non-Small-Cell Lung Cancer.Non-coding RNA · 2020Review
- miR-103/107-Mediated Suppression of NKILA Enhances Oncogenic Behaviors in Human Lung Cancer Cells.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) play an important role in the development and progression of lots of cancer. Non-small cell lung cancer (NSCLC) is all lung cancer except small cell lung cancer (SCLC). The most common non-small cell lung cancer types include squamous cell carcinoma, large cell carcinoma and adenocarcinoma, and some other common types. Increasing studies identified that a long non-coding RNA NKILA was negatively correlated with breast cancer metastasis while its clinical significance and potential role in non-small cell lung cancer (NSCLC) remain unclear. In the present study, we confirmed the function of lncRNA NKILA as well as the underlying mechanism in regulating the NSCLC.
methodsThe expression of lncRNA NKILA was detected in both Lung cancer tissues and cell line including A549 and NCI-H1299 by quantitative real-time reverse transcription. A small interfering RNA (siRNA) that targeted NKILA was transfected into cells to inhibit the expression of NKILA. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and scratch experiments were performed to analyze the migration and proliferation of NCI-H1299 which were transfected with si-NKILA. Protein levels of genes that related with G0/G1 arrest markers p16, p21, and p27 markers were measured.
resultsThe expression of NKILA was significantly down regulated in lung cancer tissues when compared to matched normal tissue.
conclusionIn summary, our results confirmed that low expression of lncRNA NKILA plays a role in the deterioration of NSCLC cells and this effect depends on IL-11/STAT3 signaling.
Indexed as
Identifiers
31934087PMC6949585W3006389873What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.