ArticleInternational journal of clinical and experimental pathology2019
Rearrangement of PDGFRβ gene in a patient with Ph-negative chronic myeloid leukemia t(5;12)(q33;p13) in imatinib mesylate treatment-free remission: a case report.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Lipopeptides fromBiotech (Basel (Switzerland)) · 2026Article
- A case of adult ETV6-ASCL6 fusion gene positive chronic myeloproliferative tumor and literature review.Pakistan journal of medical sciences · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Chronic myeloid leukemia (CML) is a hematologic malignancy, in which more than 95% of CML patients are discovered with the Philadelphia chromosome (Ph) or BCR-ABL rearrangement. Those patients mainly suffer from CML, associating with lack of tyrosine kinase activity and BCR-ABL fusion gene. Here, we reported a patient with Ph-negative CML t(5;12)(q33;p13), accompanying with a rare genetic fusion between the TEL and PDGFRβ genes. We identified a novel TEL-PDGFRβ rearrangement, joining TEL (exon 12) to PDGFRβ (exon 5), resulting in overexpression of PDGFRβ. A promising result was achieved, in which TEL-PDGFRβ fusion gene could not be effectively detected during imatinib treatment, demonstrating complete molecular biologic remission. Thus, multiple tyrosine kinase inhibitors are associated with Ph-negative CML t(5;12)(q33;p13) with TEL-PDGFRβ rearrangement.
Indexed as
Identifiers
31934053PMC6949624W3006090897What OpenQuestion holds
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