Evidence map›Paper›PMID 31934050›Full record

ArticleInternational journal of clinical and experimental pathology2019

The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.

Xiaotong Zhao, Yaqin Zhang, Lili Deng, Youming Wang, Yongxiang Li, Mingwei Chen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaotong ZhaoDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Yaqin ZhangDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Lili DengDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Youming WangDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Yongxiang LiDivision of General Surgery, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Mingwei ChenDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, People's Republic of China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the association between plasma omentin-1 levels and the risk of colorectal cancer (CRC) and the pathological changes of CRC, a total of 358 colorectal adenocarcinoma patients were included in the experience group, and 286 people were included in the control group. Their levels of omentin-1, adiponectin, visfatin, leptin, and their anthropometric and metabolic parameters were determined, and we analyzed the tertile distributions in the control group, according to the different levels: low, medium, and high. The results showed that the omentin-1 levels in patients with CRC were higher than the levels in the controls [(67.28 ± 32.25) vs (33.16 ± 19.93) ng/mL, P = 0.005]. The patients with the highest concentration of omentin-1 presented significantly higher odds for CRC, adjusted for potential confounding factors for CRC (odds ratio: 5.76; 95% CI 1.81-8.95; P = 0.001). The plasma omentin-1 level in CRC yielded a receiver operating characteristic curve area of 88.4%. The optimal sensitivity and specificity were 81.2% and 69.8% in discriminating CRC from the normal control. A high omentin-1 level was significantly associated the increasing stage of colorectal adenocarcinomas and the depth of invasion (P = 0.005, 0.026, respectively). The present study suggests an increased level of omentin-1 not only was a strong risk factor for CRC but could also represent a potential biomarker for CRC stage progression and CRC diagnosis in Chinese patients.

Indexed as

biomarkerbody mass indexChinesecolonoscopycolorectal cancerOmentin-1

Identifiers

PMID31934050
PMCPMC6949648
OpenAlexW3028145820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.