Evidence map›Paper›PMID 31934038›Full record

ArticleInternational journal of clinical and experimental pathology2019

Inhibition of CLU4A exhibits a cardioprotective role in hypoxia/reoxygenation-induced injury by an ERK-dependent pathway.

Pin Feng, Wei Zhang, Yi Chu, Jun Li, Jingxiao Yang

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pin FengDepartment of Cardiology, The Second Affiliated Hospital of Air Force Medical University Xi'an, Shaanxi, P. R. China.
Wei ZhangDepartment of Cardiology, The Second Affiliated Hospital of Air Force Medical University Xi'an, Shaanxi, P. R. China.
Yi ChuDepartment of Cardiology, The Second Affiliated Hospital of Air Force Medical University Xi'an, Shaanxi, P. R. China.
Jun LiDepartment of Cardiology, The Second Affiliated Hospital of Air Force Medical University Xi'an, Shaanxi, P. R. China.
Jingxiao YangDepartment of Cardiology, The Second Affiliated Hospital of Air Force Medical University Xi'an, Shaanxi, P. R. China.
People 's Liberation Army 451 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLU4A is identified as a proto-oncogene in various human cancers. CLU4A was reported to be up-regulated in myocardial ischemia/reperfusion injury, but the precise role of CLU4A played in myocardial ischemia/reperfusion injury remains unknown; and the underlying mechanism of CLU4A in myocardial ischemia/reperfusion injury needs to be investigated. CLU4A expression was measured after myocardial ischemia/reperfusion in mice and in H9C2 cells with hypoxia/reoxygenation treatment by q-PCR and western blotting. The cardioprotective effect of CLU4A inhibition was detected by monitoring the cell viability, cell apoptosis, and LDH activity

Indexed as

apoptosisCLU4AERK signaling pathwaysmyocardial ischemia/reperfusion injury

Identifiers

PMID31934038
PMCPMC6949645
OpenAlexW3026527795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.