ArticleInternational journal of clinical and experimental pathology2019
Silencing of DJ-1 reduces proliferation, invasion, and migration of papillary thyroid cancer cells in vitro, probably by increase of PTEN expression.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Interfered long non-coding RNA HELLPAR or up-regulated microRNA-448 inhibits nasopharyngeal carcinoma progression via suppression of ADAM10.Discover oncology · 2025Article
- MicroRNA-18b-5p Inhibits the Malignant Progression of Prostate Cancer Through Downregulating TRAF5.International journal of general medicine · 2025Article
- miR-199a/b-3p inhibits HCC cell proliferation and invasion through a novel compensatory signaling pathway DJ-1\Ras\PI3K/AKT.Scientific reports · 2024Article
- microRNA-651-5p affects the proliferation, migration, and invasion of lung cancer cells by regulating Calmodulin 2 expression.The clinical respiratory journal · 2023Article
- Review
- CENPF promotes papillary thyroid cancer progression by mediating cell proliferation and apoptosis.Experimental and therapeutic medicine · 2021Article
- The Links between Parkinson's Disease and Cancer.Biomedicines · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo explore the function of DJ-1 on cell proliferation, migration, and invasion in human papillary thyroid carcinoma (PTC) cells. MATERIALS AND
methodsDJ-1 was knocked out by siRNA in K1 and TPC-1 cells and the efficiency of siRNA was examined by qRT-PCR and western blot. Cell proliferation, cell cycle, migration, and invasion were measured by CCK-8 assay, flow cytometry, colony formation assay and trans-well assay, respectively.
resultsK1 and TPC-1 cells that were transfected with siRNA of DJ-1 had significantly lower expression levels of DJ-1 mRNA and protein. Down-regulation of DJ-1 significantly suppressed the cell proliferation, migration, and invasion. siRNA-mediated knock-down of DJ-1 increased the number of cells in the G0/G1 phase but reduced it in the S phase, while the G2/M phase was not affected. Moreover, the expression level of PTEN (Phosphatase and Tensin Homolog, PTEN) was found up-regulated in DJ-1-null cells.
conclusionsThis work suggested that DJ-1 implicated in cell proliferation, migration, and invasion of papillary thyroid cancer cells, possibly by the DJ-1/PTEN/PI3K/Akt signal pathway.
Indexed as
Identifiers
31934026PMC6949646W3005038226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.