SDF-1α promotes repair of myocardial ischemic necrosis zones in rats.

Xinhua Cai, Zhanzhan Zhu, Yongchun Zhang, Xiangqin Tian

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Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Xinhua CaiDepartment of Histology and Embryology, Xinxiang Medical University Xinxiang 453003, Henan Province, China.

Zhanzhan ZhuThe 7th People's Hospital of Zhengzhou Zhengzhou 450006, Henan Province, China.

Yongchun ZhangDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan Province, China.

Xiangqin TianDepartment of Histology and Embryology, Xinxiang Medical University Xinxiang 453003, Henan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the repair effect of stromal cell-derived factor-1α (SDF-1α) on myocardial ischemic necrosis zones.

methodsLentivirus (LV-SDF-1α-GFP) containing SDF-1α target gene was established, the separated and cultured neonatal rat cardiac fibroblasts were transfected, and caudal intravenous injection of isoproterenol was conducted to prepare a rat model of myocardial ischemia. Small animal ultrasound was used to evaluate the effect on cardiac functions. Morphology and immunofluorescence were used to observe the change of ischemic necrosis zones and expressions of stem cellular markers c-kit, CD34, nkx2.5, and nanog, and a quantitative analysis was performed.

resultsThe established LV-SDF-1α-GFP was used to transfect myocardial fibroblasts which presented GFP green fluorescent expression and could secrete SDF-1α. The small animal ultrasound system showed that rat cardiac functions of the lentivirus group and cell group were improved to different degrees, myocardial ischemic necrosis zones of lentivirus group and cell group were reduced, and differences had statistical significances (

conclusionSDF-1α can promote migration and proliferation of stem cells into the myocardial ischemic necrosis zone, participate in repair of the myocardial necrosis zone, and improve cardiac function.

Indexed as

Lentivirus vectormyocardial necrosismyocardial repairstromal cell-derived factor-1α

Identifiers

PMID31934018

PMCPMC6949651

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