A prognostic scoring model based on the HPV status of oropharyngeal carcinoma patients treated with postoperative radiotherapy in China.

Wenyan Wu, Zhen Wang, Zengtong Zhou, Jiang Li

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Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors at 1 institution in 2 countries.

Wenyan WuDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai 200011, P. R. China.

Zhen WangNational Clinical Research Center for Oral Diseases Shanghai 200011, P. R. China.

Zengtong ZhouDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai 200011, P. R. China.

Jiang LiNational Clinical Research Center for Oral Diseases Shanghai 200011, P. R. China.

National Clinical Research Center for Digestive Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrognostic models that can predict prognosis and guide postoperative radiotherapy (PRT) and that are based on the human papillomavirus (HPV) status of patients with oropharyngeal carcinoma (OPSCC) in China are rare.

methodsSurvival was analyzed by performing a Kaplan-Meier analysis and log-rank test. A Cox regression analysis was performed for the multivariate analyses. A prognostic scoring model was constructed according to the regression coefficient obtained from the Cox regression model.

resultsA prognostic model that included gender, clinical stage, histologic stage, metastasis, and HPV status was created and used to divide patients into high-risk (PI ≥ -0.008) and low-risk (PI < -0.008) groups. The results showed that the patients who received PRT had a longer overall survival time than those who did not receive PRT (47.31 months vs. 28.31 months). Furthermore, the patients who received PRT in the high-risk group had a longer survival time when the survival was greater than 20 months (P = 0.024), and PRT may indicate a worse prognosis in the low-risk group (P = 0.071).

conclusionThis model will contribute to the formulation of individualized treatment programs for OPSCC patients. PRT should be administered to high-risk patients.

Indexed as

human papillomavirusOropharyngeal squamous cell carcinomapostoperative radiotherapyprognostic model

Identifiers

PMID31934010

PMCPMC6947130

OpenAlexW3006428826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.