ArticleInternational journal of clinical and experimental pathology2019
Vitamin D deficiency enhances insulin resistance by promoting inflammation in type 2 diabetes.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: a systematic review of randomized controlled trials.BMC endocrine disorders · 2025Pooled it
- Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Serum and supplemental vitamin D levels and insulin resistance in T2DM populations: a meta-analysis and systematic review.Scientific reports · 2023Pooled it
- Correlation of vitamin D levels with TNF-α and IL-6 expression in insulin-resistant type 2 diabetes mellitus patients.Scientific reports · 2026Article
- Dietary Supplements Derived from Food By-Products for the Management of Diabetes Mellitus.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression.Scientific reports · 2025Article
- Correlation between serum vitamin levels and gestational diabetes mellitus.Frontiers in endocrinology · 2025Review
- Effect of thymoquinone on vitamin D metabolism in glucocorticoid-induced insulin resistance.Iranian journal of basic medical sciences · 2025Article
- Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes.Biomedicines · 2024Review
- The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art.International journal of molecular sciences · 2023Review
- Serum 25-Hydroxyvitamin D Levels in Type 2 Diabetes Patients in North China: Seasonality and the Association between Vitamin D Status and Glycosylated Hemoglobin Levels.International journal of clinical practice · 2023Article
- Article
- Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women.Healthcare (Basel, Switzerland) · 2022Review
- Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women.Turkish journal of medical sciences · 2022Article
- Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections-Sepsis and COVID-19.Nutrients · 2022Article
- Dietary Magnesium Intake Level Modifies the Association Between Vitamin D and Insulin Resistance: A Large Cross-Sectional Analysis of American Adults.Frontiers in nutrition · 2022Article
- Expression of TNF-Computational and mathematical methods in medicine · 2022Article
- Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview.International journal of endocrinology · 2022Review
- Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was aimed to analyze the level of serum 25(OH)D in patients with type 2 diabetes (T2DM), and explore the relationship between serum 25(OH)D and insulin resistance.
methods60 health people and 106 patients with T2DM were measured the level of serum 25(OH)D, fasting blood glucose, insulin, TNF-α, IL-6, IL-8, and IL-1β, etc. We established a rat model of T2DM and vitamin D (VD) deficiency, and studied the effects of VD deficiency on homeostasis model assessment insulin resistance (HOMA-IR) and pancreatic inflammation.
resultsThe level of serum 25(OH)D in patients with T2DM was significantly lower than that in health people, and HOMA-IR decreased with the increasing of the serum 25(OH)D level. Pearson correlation analysis showed that the serum 25(OH)D level in patients with T2DM had a negative correlation with HOMA-IR (r=-0.750, P<0.001), TNF-α (r=-0.705, P<0.001), IL-1β (r=-0.661, P<0.001), IL-8 (r=-0.645, P<0.001), and IL-6 (r=-0.609, P<0.001). In animal experiment, Vitamin D deficiency enhanced HOMA-IR in rats with T2DM and reversed it by supplementing VD. Vitamin D deficiency could increase the inflammatory response by up-regulating p-p65/RelB in the pancreas tissue.
conclusionSerum 25(OH)D was elevated and Vitamin D deficiency enhanced insulin resistance by promoting inflammation via NF-kB pathway in patients with T2DM.
Indexed as
Identifiers
31934009PMC6947100W3009499440What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.