ArticleInternational journal of clinical and experimental pathology2019
Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid arthritis.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Metabolic and neuroimmune control of rheumatoid arthritis: therapeutic implications of FXR and α7-nAChR axes.Inflammopharmacology · 2026Review
- Identification and Experimental Verification of PDK4 as a Potential Biomarker for Diagnosis and Treatment in Rheumatoid Arthritis.Molecular biotechnology · 2025Article
- From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered.Molecular neurobiology · 2025Article
- Transforming growth factor-beta is increased in sputum from individuals with rheumatoid arthritis-associated pulmonary fibrosis.Rheumatology (Oxford, England) · 2025Article
- Citrullinated and malondialdehyde-acetaldehyde-modified fibrinogen activates macrophages and promotes profibrotic responses in human lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Shared immunological pathways in rheumatoid arthritis-related interstitial lung disease.Frontiers in immunology · 2025Review
- At Early Rheumatoid Arthritis Stage, the Infectious Spectrum Is Driven by Non-Familial Factors and Anti-CCP Immunization.Journal of clinical medicine · 2024Article
- Low-frequency and rare genetic variants associated with rheumatoid arthritis risk.Nature reviews. Rheumatology · 2024Review
- Peripheral Blood Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Review.ACR open rheumatology · 2023Article
- Role and mechanism of fibroblast-activated protein-α expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis.Frontiers in immunology · 2023Review
- The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children.BMC molecular and cell biology · 2022Article
- Asthma Promotes Choroidal Neovascularization via the Transforming Growth Factor Beta1/Smad Signalling Pathway in a Mouse Model.Ophthalmic research · 2022Article
- Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis.Tissue engineering. Part A · 2021Article
- MicroRNA-23a-5p regulates cell proliferation, migration and inflammation of TNF-α-stimulated human fibroblast-like MH7A synoviocytes by targeting TLR4 in rheumatoid arthritis.Experimental and therapeutic medicine · 2021Article
- Rheumatoid cachexia: the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche.Journal of biomedical science · 2021Review
- Therapeutic Effect of Exogenous Regulatory T Cells on Collagen-induced Arthritis and Rheumatoid Arthritis.Cell transplantationArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored whether transforming growth factor (TGF-β)/Smads signaling pathway influences rheumatoid arthritis (RA)-associated pulmonary fibrosis (PF) and proliferation of RA synovial fibroblast (RA-SF). Expression levels of TGF-β1 in RA + PF patients, RA patients and healthy controls were determined. Rat models of RA were successfully induced and assigned into groups. The mRNA, phosphorylation and protein expressions of TGF-β1, Smad2 and Smad3 were detected. The serum expressions of inflammatory factors were measured by ELISA. Tissue sections were observed using hematoxylin-eosin (HE) and Masson staining. The SF cells were separated and grouped. Cell viability and migration were determined. The highest expressions of TGF-β1 were found in RA + PF patients, followed by RA patients and then healthy controls. RA + PF rats were characterized by less activity, worse appetite, messy and less shining hair, thin sloppy stool and increased joint swelling. Compared with the normal group, the expressions of TGF-β1, Smad2, Smad3, IL-6 and TNF-α were elevated in the RA + PF group. Meanwhile, the swelling and pulmonary fibrosis of lung tissues was worse, the lung capacity and serum level of IL-10 were decreased. However, SB431542 can reverse the above results. The cell activity and cell migration ability of cells in the RA + PF + SB431542 group were inhibited compared to those in the blank group. Based on above findings, the inhibition of the TGF-β/Smads signaling pathway alleviates the pulmonary fibrosis in rats with RA and suppresses cell viability and migration of synovial fibroblasts.
Indexed as
Identifiers
31934007PMC6947118W3004425117What OpenQuestion holds
Registered trials
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