ArticleInternational journal of clinical and experimental pathology2019
Mucin-1 expression and localization in epithelial cells shows characteristic and distinct patterns in inflammatory bowel diseases and colorectal cancer.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- Clinical Significance of Mucin Signatures in Inflammatory Bowel Diseases: A Systematic Review of Their Expression Patterns, Polymorphisms, and Post-translational Modifications.Inflammatory bowel diseases · 2026Pooled it
- Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond.Frontiers in immunology · 2022Pooled it
- "Remodeling the intestinal immune microenvironment": immune regulation and tissue regeneration by mesenchymal stem/stromal cells in the repair microenvironment of inflammatory bowel disease.Frontiers in immunology · 2025Review
- MUC1 and MUC5AC implication in Tunisian colorectal cancer patientsTurkish journal of medical sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in colonic mucus secretion are linked to the induction and maintenance of inflammation during inflammatory bowel disease (IBD) and its progression to colorectal cancer (CRC). MUC1, a multifunctional glycoprotein, is the best studied cell surface mucin in mouse models of IBD and CRC. However, little information on MUC1 expression and localization in different types of pathologic human colon mucosa is available. In this work, expression and subcellular localization of MUC1 in different types of diseased human colon mucosa from a cohort of Tunisian patients is analyzed and correlated with the type of disorder. Colon tissue samples were obtained from 39 cases of CRC and 18 cases of IBD. 13 cases of normal adjacent colon mucosa tissues served as controls. Biopsies were subjected to immunohistochemical analysis of MUC1 expression. Signals were quantified densitometrically and characterized with regard to tissue and intracellular distribution. Results were then correlated with the different types of colon disorder. Immunohistochemical investigation of MUC1 in a cohort of inflammatory bowel diseases and colorectal cancer showed a significant divergence in the expression of MUC1 in terms intensity (18.96% ± 0.55 vs 27.26% ± 1.24 respectively; P=0.005) and localization between the two types of lesions (30.76% vs 70.96% respectively; P=0.0199). Our findings show divergent characteristic patterns for MUC1 expression and localization in different types of pathologic alterations of the colon mucosa. These results are of potential diagnostic and predictive clinical value.
Indexed as
Identifiers
31933991PMC6947141W3005595417What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.