Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor.

Jinhai Wang, Xiaobin Cheng, Sen Lu, Weina Fan

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Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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4 authors at 1 institution in 1 country.

Jinhai WangDepartment of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.

Xiaobin ChengDepartment of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.

Sen LuDepartment of Colorectal Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.

Weina FanDepartment of Intensive Care Unit, The First Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, P. R. China.

First Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOsteopontin (OPN) is reported to be particularly associated with the progression of several human malignancies. This study was designed to examine the clinicopathologic significance of OPN in gastrointestinal stromal tumor (GISTs).

methodsThe level of OPN expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with the clinicopathologic parameters of patients with resectable GISTs was analyzed. A survival analysis was performed to evaluate the prognostic significance of OPN expression using the Kaplan-Meier method.

resultsIn 108 patients with resectable GISTs, the most high-risk GISTs had a strong level of OPN expression. Strong OPN expression was also significantly associated with tumor size, mitosis, and recurrence, but not gender and age. Patients with weak OPN expression had a relatively longer disease-free survival compared to patients with strong OPN expression.

conclusionsOPN expression is a putative marker for tumor progression and an adverse prognosis in GISTs.

Indexed as

gastrointestinal stromal tumorsimmunohistochemistryOsteopontinprognosis

Identifiers

PMID31933953

PMCPMC6947051

OpenAlexW3026918948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.