Evidence map›Paper›PMID 31933952›Full record

ArticleInternational journal of clinical and experimental pathology2019

Correlations of PCNA expression with thyroid cancer ultrasound and histopathologic features.

Debin Yang, Xiaohua Yao, Jie Zhou, Haihua Zhou, Guofeng Lu, Yingchun Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. BRAF Detection in FNAC Combined with Semi-QuantitativeDiagnostics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Debin YangDepartment of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Xiaohua YaoDepartment of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Jie ZhouDepartment of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Haihua ZhouDepartment of General Surger, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Guofeng LuDepartment of Pathology, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Yingchun WangDepartment of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai, China.
Jiading District Central Hospital · CNShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the correlations of proliferating cell nuclear antigen (PCNA) gene expression with thyroid cancer (TC) ultrasound (US) features, histopathology and clinical stage.

methodsA total of 66 TC patients admitted and treated in the Department of Oncology of our hospital from April 2014 to April 2018 were enrolled randomly. The conventional US imaging data of the patients were collected. Paired carcinoma and para-carcinoma tissues were obtained after operation to detect the expression of PCNA protein by immunohistochemistry (IHC). The correlations of PCNA expression with the patients' US manifestations and clinical stages were analyzed.

resultsThe positive rate of PCNA was 72.73% (48/66) in TC tissues and 13.64% (9/66) in paired para-carcinoma tissues, displaying a statistically significant difference between the two groups (

conclusionThe expression of PCNA protein in TC tissues is significantly correlated with the diameter, echo, calcification and blood flow of US features as well as clinical stage detected by US. PCNA level and US examination can provide certain clinical values for TC treatment.

Indexed as

PCNAThyroid cancertumor stageultrasound

Identifiers

PMID31933952
PMCPMC6947062
OpenAlexW3009873616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.