ArticleInternational journal of clinical and experimental pathology2019
LncRNA linc01116 prometes glioma cell migration and invasion by modulation of radixin targeted by miR-31.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- High linc01116 expression may contribute to a poor prognosis in various cancers based on systematic reviews and meta-analyses.BMC cancer · 2024Pooled it
- Review
- Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma.Molecular cell · 2022Article
- Non-coding RNAs and glioblastoma: Insight into their roles in metastasis.Molecular therapy oncolytics · 2022Review
- Development and validation of stemness associated LncRNA based prognostic model for lung adenocarcinoma patients.Cancer biomarkers : section A of Disease markers · 2022Article
- lncRNA NEAT1 promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the FOXP3/PKM2 axis.Frontiers in oncology · 2022Article
- Dysregulation of lncRNAs in circulation of patients with periodontitis: results of a pilot study.BMC oral health · 2021Article
- Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients.Annals of translational medicine · 2021Article
- Long non-coding RNA LINC01116 acts as an oncogene in prostate cancer cells through regulation of miR-744-5p/UBE2L3 axis.Cancer cell international · 2021Article
- Knocking down LINC01116 can inhibit the regulation of TGF-β through miR-774-5p axis and inhibit the occurrence and development of glioma.American journal of translational research · 2021Article
- Cytoskeletal Remodeling in Cancer.Biology · 2020Review
- Long non-coding RNA LINC01116 is overexpressed in lung adenocarcinoma and promotes tumor proliferation and metastasis.American journal of translational research · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong non-coding RNA (lncRNA) linc01116 was found to be abnormally expressed in many malignant tumor tissues and involved in cancer progression, but its expression and role in glioma tissue is still unclear. This study was designed to investigate the expression of linc01116 in glioma tissues and the role of linc01116 in glioma cell migration and invasion.
methodsLinc01116 and miR-31 expression was measured in 135 cases of human glioma tissues and normal brain tissues using Real-time quantitative PCR (RT-qPCR). The function of linc01116 in glioma cells was determined by Transwell invasion assays and nude mice metastasis assay. Luciferase reporter system was used to confirm the connection between linc01116 and miR-31, or miR-31 and radixin.
resultsLinc01116 is highly expressed in glioma tissue and cells, along with low expression of miR-31, and there was a negative correlation between the expression of linc01116 and miR-31 in glioma tissue. In addition, the expression of linc01116 in glioma patients with metastasis was significantly higher than that in patients without metastasis, while miR-31 was significantly lower. In vitro and in vivo studies shown that linc01116 promoted invasion and migration of glioma cells. The luciferase gene reporter system had confirmed that linc01116 targeted miR-31 and miR-31 targeted radixin in U251 cells. Moreover, radixin was downregulated and decreased E-cadherin protein expression, but increased MMP-9 and vimentin protein expression in U251 cells.
conclusionLncRNA linc01116 is highly expressed in glioma tissues, and it promotes glioma cell migration and invasion by modulation of radixin targeted by miR-31.
Indexed as
Identifiers
31933922PMC6945163W3005260777What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.