Evidence map›Paper›PMID 31933904›Full record

ArticleInternational journal of clinical and experimental pathology2019

Circular RNA DLGAP4 is down-regulated and negatively correlates with severity, inflammatory cytokine expression and pro-inflammatory gene miR-143 expression in acute ischemic stroke patients.

Xiaoqi Zhu, Ji Ding, Beiyun Wang, Jie Wang, Min Xu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaoqi ZhuDepartment of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Ji DingDepartment of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Beiyun WangDepartment of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Jie WangDepartment of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Min XuDepartment of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Renji Hospital · CNShanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the expression of circular RNA DLGAP4 (circ-DLGAP4) and its correlation with severity, inflammation, inflammatory cytokine levels as well as microRNA-143 (miR-143) expression in acute ischemic stroke (AIS) patients. One hundred and seventy AIS patients and 170 non-AIS controls were enrolled in this study. PBMC and serum from all participants were collected. Circ-DLGAP4 and miR-143 expression in PBMC were detected by qPCR, and TNF-α, IL-1β, IL-6, IL-8, IL-17 as well as IL-22 expressions in serum were detected by ELISA. The information of CRP, ESR, and National Institutes of Health Stroke Scale (NIHSS) score of AIS patients was collected. PBMC circ-DLGAP4 was down-regulated in AIS patients compared with controls, and ROC curve analysis disclosed that PBMC circ-DLGAP expression had good value in predicting lower AIS risk with area under curve 0.816. Spearman's rank correlation test showed that PBMC circ-DLGAP4 expression negatively correlated with NIHSS score and CRP level in AIS patients. In addition, PBMC circ-DLGAP4 level also was negatively associated with serum expressions of TNF-α, IL-6, IL-8 as well as IL-22. Moreover, PBMC circ-DLGAP4 expression was negatively correlated with PBMC miR-143, and PBMC miR-143 was positively associated with NIHSS score, CRP, ESR, TNF-α, IL-1β, IL-6, IL-8, IL-17, as well as IL-22 levels. Circulating circ-DLGAP4 could serve as a novel biomarker for diagnosis and disease surveillance of AIS and is negatively correlated with inflammation and miR-143 expression in AIS patients.

Indexed as

Acute ischemic strokecirc-DLGAP4inflammationmiR-143severity

Identifiers

PMID31933904
PMCPMC6945178
OpenAlexW3028457489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.