ArticleInternational journal of clinical and experimental pathology2019
The balance between HGF and TGF-β1 acts as a switch in the tissue remodeling of chronic rhinosinusitis.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities.Frontiers in immunology · 2026Review
- Understanding the Renal Fibrotic Process in Leptospirosis.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe remodeling patterns in different types of chronic rhinosinusitis (CRS) are controversial. This study aimed to investigate the roles of transforming growth factor-β1 (TGF-β1) and hepatocyte growth factor (HGF) in the CRS remodeling process.
methodsSurgical samples were obtained from CRSwNP patients (n=29), CRSsNP patients (n=34), and controls (n=21). Collagen deposition was detected via Masson trichrome (MT) staining. Immunohistochemical staining was performed to examine the protein expression of α-smooth muscle actin (α-SMA). The expression of TGF-β1 and HGF was measured by ELISA. The relationship between the rate of TGF-β1/HGF and the expression of Collagen III and α-SMA was analyzed using a Pearson correlation test. Primary nasal epithelial cells (NECs) were cultured and divided into four groups. Collagen III secretion was measured in the supernatants by ELISA. The expression of α-SMA was studied by immunofluorescence.
resultsReduced collagen deposition and α-SMA expression were detected in the CRSwNP group (P=0.033). The expression of collagen deposition and α-SMA was increased in the CRSwNP group (P=0.001). The ELISA tests indicated that TGF-β1 levels were significantly increased in the CRSsNP compared with the controls. The expression of HGF was higher in the CRSwNP than in the other two groups. The ratio of TGF-β1/HGF was upregulated in CRSsNP and was correlated positively with collagen and α-SMA expression (P<0.05, R=0.762). TGF-β1 can increase collagen and α-SMA expression in NECs, and HGF can antagonize the remodeling action of TGF-β1.
conclusionDistinct remodeling patterns are revealed for different types of CRS. The balance of TGF-β1 and HGF is important in the CRS remodeling process.
Indexed as
Identifiers
31933903PMC6945174W3007958412What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.