ArticleInternational journal of clinical and experimental pathology2019
Melatonin attenuates early brain injury after subarachnoid hemorrhage by the JAK-STAT signaling pathway.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic intracranial hemorrhage patients: a randomized controlled trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Trial
- The Effect of Tart Cherry on Sleep Quality and Sleep Disorders: A Systematic Review.Food science & nutrition · 2025Review
- Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges.Molecular neurobiology · 2025Review
- Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review.Translational stroke research · 2023Review
- Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury.Frontiers in aging neuroscience · 2023Review
- Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19.International journal of molecular sciences · 2022Review
- Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage.Neural regeneration research · 2022Review
- Ferrostatin-1 Polarizes Microglial Cells Toward M2 Phenotype to Alleviate Inflammation After Intracerebral Hemorrhage.Neurocritical care · 2022Article
- Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies.Frontiers in immunology · 2022Review
- Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury.Frontiers in aging neuroscience · 2022Review
- Eucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model.Pharmaceutical biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing studies have demonstrated the neuroprotective effect of melatonin in central nervous system (CNS) diseases. However, the potential application of melatonin in therapy of subarachnoid hemorrhage (SAH) is still unclear. This study explored the potential effect of melatonin on early brain injury (EBI) induced by SAH and investigated the underlying mechanisms. Adult rats were subjected to SAH. Melatonin or vehicle was injected intraperitoneally 2 hr after SAH. The mortality, SAH grade, neurologic score, brain water content, and neuronal apoptosis were evaluated. To explore further mechanisms, changes in JAK1/STAT3 signaling pathway and the levels of apoptosis-associated proteins were also examined. The results suggest that melatonin improved the neurologic deficits and reduced the brain water content and neuronal apoptosis. In addition, The JAK1 inhibitor, Ruxolitinib, was applied to manipulate the proposed pathway. Mortality, neurological scores, brain edema, cell apoptosis, and the expression of JAK1, STAT3, and cleaved caspase-3 proteins were assayed after 24 h SAH. Melatonin significantly improved neurological function and reduced neuronal apoptosis and brain edema at 24 h after SAH. The level of JAK1 was markedly up-regulated. Additionally, the level of cleaved caspase-3 was decreased by melatonin treatment. The beneficial effects of melatonin in SAH rats were partially suppressed by Ruxolitinib. In summary, our results demonstrate that melatonin treatment attenuates EBI following SAH via the JAK1/STAT3 signaling pathway.
Indexed as
Identifiers
31933900PMC6945149W3028047632What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.