ArticleInternational journal of clinical and experimental pathology2019
The role of autophagy and Beclin-1 in radiotherapy-induced apoptosis in thyroid carcinoma cells.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Autophagy in thyroid cancer: stage-dependent switch, mutation-specific regulation, and therapeutic targeting.Oncology reviews · 2026Review
- Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption.Scientific reports · 2025Article
- Article
- Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment.Frontiers in immunology · 2024Review
- The new insights into autophagy in thyroid cancer progression.Journal of translational medicine · 2023Review
- [Chloroquine enhances cisplatin-induced apoptosis of nasopharyngeal carcinoma cells by inhibiting autophagy via upregulating miR129].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- The Roles of Beclin 1 Expression in Gastric Cancer: A Marker for Carcinogenesis, Aggressive Behaviors and Favorable Prognosis, and a Target of Gene Therapy.Frontiers in oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThyroid cancer (TC), especially primary squamous cell carcinoma (SCC), is an aggressive malignant tumor which usually resists radiotherapy (RT). We wanted to understand the mechanism of incomplete response of RT in TC cells.
methodsSCC cell line SW579 cells were exposed to X-rays. Apoptosis and autophagy were measured by FACS; 3MA, inhibitor of autophagy, and Beclin-1 siRNA were used to investigate the effect of autophagy on radiation-induced TC cell apoptosis.
resultsRT could induce TC cell apoptosis through death receptor as well as mitochondrial pathway. Radiotherapy also induces autophagy and increases expression of autophagy-associated proteins Beclin-1 and LC3. Moreover, inhibition of autophagy by 3MA and Beclin-1 siRNA enhanced radiation-induced apoptosis, through up-regulation of the expression of p53.
conclusionRT-induced autophagy resists apoptosis by the p53 pathway and an incomplete response to RT may be associated with autophagy in TC patients.
Indexed as
Identifiers
31933897PMC6945190W3007228391What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.