ArticleInternational journal of clinical and experimental pathology2019
The attenuation of myocardial hypertrophy by atorvastatin via the intracellular calcium signal and the p38 MAPK pathway.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy.British journal of pharmacology · 2023Article
- Integrins in cardiac hypertrophy: lessons learned from culture systems.ESC heart failure · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt is well documented that atorvastatin could protect against atherosclerosis, cardiac fibrosis, etc. However, few reports have drawn the link between atorvastatin and myocardial hypertrophy, a common type of myocardial damage. This study aimed to illustrate the effects of atorvastatin on Ang II-induced cardiac hypertrophy and to reveal its mechanism.
methodsWe established cardiac hypertrophy by exposing cardiomyocytes to Ang II. Then we determined whether atorvastatin could reverse cardiac hypertrophy markers and several cellular responses induced by Ang II to normal levels. Finally, we tried to illustrate the mechanism of these effects.
resultsAtorvastatin performed very well in resuming cardiac hypertrophy. It could attenuate the increase of oxidative stress and cell apoptosis in cardiomyocyte cells. The activation of the p38 MAPK signaling pathway induced by Ang II was well inhibited by atorvastatin. Additionally, the Ca
conclusionAtorvastatin can attenuate cardiac hypertrophy induced by Ang II via the intracellular calcium signal and the p38 MAPK pathway. It provides a therapeutic potential for the treatment of myocardial hypertrophy.
Indexed as
Identifiers
31933887PMC6945148W3004789261What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.