ArticleInternational journal of clinical and experimental pathology2019
GSK-3β mediates ischemia-reperfusion injury by regulating autophagy in DCD liver allografts.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Novel Perspectives in Hepatic Ischemia-Reperfusion Injury: The cGAS-STING Pathway.Journal of inflammation research · 2025Review
- Regulation of autophagy protects against liver injury in liver surgery-induced ischaemia/reperfusion.Journal of cellular and molecular medicine · 2021Review
- New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases.Frontiers in cell and developmental biology · 2021Review
- Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the role of autophagy in ischemia-reperfusion injury (IRI) and determine whether glycogen synthase kinase-3β (GSK-3β) plays an important role in autophagy, a donors of cardiac death (DCD) liver transplantation model was established to observe the expression of GSK-3β and autophagy in hepatocytes during liver IRI. Immunohistochemical staining and western blotting were used to detect expression of the autophagy markers, LC3 and p62, as well as study the expression of GSK-3β and AMPK. Serum enzymology changes were analyzed at different times after liver transplantation. Hypoxia-reoxygenation methods were used to mimic the process of ischemia-reperfusion injury in cultured hepatocytes. In DCD liver transplantation with a prolonged reperfusion time, LC3 expression increased, whereas p62 decreased. GSK-3β and AMPK expression in the transplanted liver tissue were consistent with changes in autophagy, ALT, and AST. In summary, inactive GSK-3β reduced liver IRI, promoted hepatocyte autophagy, and improved hepatocyte activity. Therefore, GSK-3β may regulate autophagy through the AMPK-mTOR pathway.
Indexed as
Identifiers
31933870PMC6945083W3005878447What OpenQuestion holds
Registered trials
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