Evidence map›Paper›PMID 31933866›Full record

ArticleInternational journal of clinical and experimental pathology2019

RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis.

Nathaniel Melling, Kai Bachmann, Maximillian Bockhorn, Oliver Mann, Jakob Robert Izbicki, Katharina Grupp

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nathaniel MellingGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Kai BachmannGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Maximillian BockhornGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Oliver MannGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Jakob Robert IzbickiGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Katharina GruppGeneral, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRetinoic acid-induced gene 3 (

findingsRAI3 protein expression was predominantly localized in the cell membrane and was detectable in low intensities in most of the benign gastric tissue samples. RAI3 expression was found in increased intensities in premalignant and malignant epithelium relative to non-malignant gastric epithelium (P < 0.0001). High RAI3 expression was found in 66.2% of interpretable gastric adenocarcinomas and was associated with advanced pathological tumor stage (P = 0.0014) and positive lymph node status (P = 0.0137) but was unrelated to overall survival of patients (P = 0.3743).

conclusionThe deregulation of RAI3 in premalignant and gastric epithelium suggests a relevant role of RAI3 during gastric carcinogenesis. Additionally, RAI3 overexpression defines a subset of GCs with aggressive tumor features. However, since RAI3 expression was not associated with clinical outcome of patients, RAI3 cannot be considered as a prognostic biomarker in patients with GCs.

Indexed as

gastric adenocarcinomagastric dysplasiaimmunohistochemistryRAI3tissue microarray

Identifiers

PMID31933866
PMCPMC6945097
OpenAlexW3026066812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.