ArticleInternational journal of clinical and experimental pathology2019
Expression of miR-141 and YAP1 in gastric carcinoma and modulation of cancer cell proliferation and apoptosis.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- The role of miR-200 family in the regulation of hallmarks of cancer.Frontiers in oncology · 2022Review
- Small RNA sequencing to differentiate lung squamous cell carcinomas from metastatic lung tumors from head and neck cancers.PloS one · 2021Article
- A methylation-based mRNA signature predicts survival in patients with gastric cancer.Cancer cell international · 2020Article
- Targeting Yes1 Associated Transcriptional Regulator Inhibits Hepatocellular Carcinoma Progression and Improves Sensitivity to Sorafenib: An in vitro and in vivo Study.OncoTargets and therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yes-associated protein 1 (YAP1) plays important roles in facilitating cell proliferation and decreasing apoptosis and is related to gastric cancer. Abnormal down-regulation of miR-141 is associated with gastric cancer pathogenesis, suggesting a potentially tumor suppressor role. Bioinformatics analysis found complementary binding sites between miR-141 and YP1. This study investigated the role of miR-141 in mediating YAP1 expression and biological behavior of gastric cancer cells. Gastric cancer tissues were collected using normal mucosal tissues as the control. qRT-PCR compared expression of miR-141 and YAP1 mRNA, and western blot quantified YAP1 protein expression. Spearman approach analyzed the correlation between miR-141 and YAP1 mRNA in cancer tissues. Dual luciferase reporter gene assay confirmed the targeted regulation between miR-141 and YAP1. Using GES-1 cell as the control, miR-141 and YAP1 expression were measured in gastric cancer cell lines SGC7901 and MGC03. Those cells were transfected with miR-141 mimic in the presence or absence of miR-YAP1 mimic followed by flow cytometry for apoptosis and EdU staining for proliferation. Cancer tissues had decreased miR-141 and higher YAP1 expression, which was associated with TNM stage. YAP1 mRNA and miR-141 were positively correlated (
Indexed as
Identifiers
31933860PMC6945079W3012615584What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.