ArticleInternational journal of clinical and experimental pathology2019
Prognostic significance of BZW2 expression in lung adenocarcinoma patients.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- m6A methyltransferase METTL3 facilitates multiple myeloma cell growth through the m6A modification of BZW2.Annals of hematology · 2023Article
- Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.Current issues in molecular biology · 2023Article
- Analysis of the role of Ly-1 antibody reactive in different cancer types.Bioengineered · 2021Article
- PLP2 Expression as a Prognostic and Therapeutic Indicator in High-Risk Multiple Myeloma.BioMed research international · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung adenocarcinoma (LUAD) is the most common pathologic subgroup of lung cancer. The role of basic leucine zipper and W2 domains 2 (BZW2) in tumorigenesis has been investigated, while the functions and molecular mechanisms of BZW2 in LUAD remain undetermined. Our study aimed to investigate the effect of BZW2 in LUAD tumorigenesis and prognostic prediction. LUAD patients who underwent complete resection with tumor available for histologic evaluation were collected, and immunohistochemistry (IHC) was performed and scored for intensity of BZW2 expression. Overall survival (OS) and disease free survival (DFS) were estimated and compared between groups. Hazard ratios (HRs) for death were estimated using univariable and multivariable Cox proportional hazards models. BZW2 was considerably raised in the archival tissue samples from LUAD patients relative to those in healthy controls. High BZW2 expression was associated with unfavorable OS and DFS in LUAD patients. Coincidently, the up-regulated BZW2 was related to tumorigenesis, including tumor size, stage, and lymphatic invasion. In addition, we also found a positive correlation between
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31933829PMC6949873W3007683801What OpenQuestion holds
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