ArticleInternational journal of clinical and experimental pathology2019
CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion.Cell death & disease · 2026Article
- Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology.Molecular oncology · 2024Article
- TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis.International journal of biological sciences · 2024Article
- Article
- Development of a prognostic model for anoikis and identifies hub genes in hepatocellular carcinoma.Scientific reports · 2023Article
- Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma.World journal of gastrointestinal oncology · 2023Article
- Fatty acid metabolism: A new therapeutic target for cervical cancer.Frontiers in oncology · 2023Review
- CD147: an integral and potential molecule to abrogate hallmarks of cancer.Frontiers in oncology · 2023Review
- OIP5-AS1/CD147/TRPM7 axis promotes gastric cancer metastasis by regulating apoptosis related PI3K-Akt signaling.Frontiers in oncology · 2023Article
- Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a NovelInternational journal of molecular sciences · 2022Article
- Expression of CD147 after neoadjuvant chemotherapy and its relationship with prognosis in patients with triple negative breast cancer.American journal of translational research · 2022Article
- Article
- Impact of Epithelial-Mesenchymal Immunophenotype on Local Aggressiveness in Papillary Thyroid Carcinoma Invading the Airway.Journal of clinical medicine · 2021Article
- Discovery and Biological Evaluation of CD147Molecules (Basel, Switzerland) · 2020Article
- Immunohistochemical basigin expression level in thyroid cancer tissues.World journal of surgical oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD147 is a transmembrane glycoprotein that when highly expressed contributes to tumor progression. In the present study, we investigate the clinical relevance of CD147 expression in CCSC tissues and evaluate the association between CD147 expression and cervical lymph node metastasis; CD147 was detected using immunohistochemistry. To functionally analyze the role of CD147 in CCSC cell lines in vitro, SiHa cells were employed, whose endogenous CD147 was artificially downregulated, by using lentiviral-based transfection. Moreover, we have confirmed that knockdown of CD147 led to reduced levels of cellular lipid content in shCD147 cells by BODIPY staining. Cell invasion and migration were analyzed using transwell assays and wound healing. Angiogenesis and lymphangiogenesis were assessed by an endothelial cell tube formation assay. Our data showed that highly expressed CD147 up-regulated the major lipogenic genes, FAS and ACC1 to promote de novo lipogenesis, and knockdown of CD147 significantly inhibited the migration and invasion of CSCC cells. The culture supernatants of CD147 knockdown cells significantly inhibited vascular and lymphatic endothelial cell tube formation. Our results suggest that CD147-mediated FAS and ACC1 overexpression are major regulators of cervical cancer growth and metastasis.
Indexed as
Identifiers
31933828PMC6949868W3002587898What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.