αB crystalline upregulates the expression of matrix metalloproteinases in trabecular meshwork cells through TLR1/2.

Yu Wang, Li Zhu, Xin Tang, Hui Xu, Yongzhen Bao

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Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Yu WangDepartment of Ophthalmology, Peking University People's Hospital Beijing, China.

Li ZhuDepartment of Ophthalmology, Peking University People's Hospital Beijing, China.

Xin TangDepartment of Ophthalmology, Peking University People's Hospital Beijing, China.

Hui XuDepartment of Ophthalmology, Peking University People's Hospital Beijing, China.

Yongzhen BaoDepartment of Ophthalmology, Peking University People's Hospital Beijing, China.

Beijing Institute of Petrochemical Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur previous study identified the TLR1/2 complex as the receptor for αB crystalline (CRYAB). Here, we aimed to determine whether CRYAB could influence the expression of matrix metalloproteinases (MMPs) in trabecular meshwork (TM) cells through TLR1/2.

methodsThe expression of P65, P38, ERK and JNK, which are downstream of TLR1/2, was identified by western blot (WB) with the interference of a TLR1/2 inhibitor or siRNA-TLR1 (siRNA-TLR2). MMP2 and MMP9 were tested by WB analyses using the same interference conditions in TM cells. C57BL/6N mice were used to study the effects

resultsFor the NF-κB pathway, the expression of P65 was increased in TM cells with the addition of exogenous CRYAB (

conclusionCRYAB triggers the activation of MMPs in TM cells

Indexed as

extracellular matrixNF-κBTLR1/2 complextrabecular meshwork cells (TM cells)αB crystalline (CRYAB)

Identifiers

PMID31933821

PMCPMC6949787

OpenAlexW3006740094

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Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.