ArticleInternational journal of clinical and experimental pathology2019
Superficial spreading squamous cell carcinoma in situ of the cervix involving the endometrium: a rare case presentation and review of literature.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Superficial Spread of Nonkeratinizing Squamous Cell Carcinoma of the Cervix to the Endometrium: A Case Report.Cureus · 2024Article
- Superficial Spreading, Microinvasive CIN 3 of Cervix: Report of an Unusual Pattern of Endometrial Involvement.Journal of obstetrics and gynaecology of India · 2022Article
- Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: a case report and review of the literature.Journal of medical case reports · 2022Review
- Unusual Extension of Superficial Spreading Squamous Cell Carcinoma of Cervix to Uterus, Paraovarian, Paratubal Tissue, and Vaginal Surface: A Unique Case Report.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSquamous cell carcinoma in situ of the cervix rarely can spread superficially to the inner surface of the uterus replacing the endometrium. CASE: We report a case of cervical squamous cell carcinoma in situ (CIS) in a 66-year-old female with contiguous extension to the endometrium with small foci of microinvasion. Immunohistochemistry revealed that these tumor cells were positive for p16, p63, and ck5/6 with a high Ki-67 labelling index. It is an extremely unusual phenomenon for cervical CIS superficial to spread to the endometrium.
conclusionCervical CIS can also spread superficially upward, and replace the endometrial lining. The detection of immunohistochemical expression of p16, p63 and CK5/6 in the lesions of cervix and the endometrium suggest that these two lesions are etiologically related, favoring the possibility of the endometrium SCC secondary to cervical SCC in situ, and reveal that HPV is a causative factor for superficial spreading SCC.
Indexed as
Identifiers
31933815PMC6949783W3012399029What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.