ArticleInternational journal of clinical and experimental pathology2019
Regulation of calcium pump through Notch/Jagged/Hes signaling pathway in canine model of chronic atrial fibrillation.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveUsing a canine model of atrial fibrillation (AF) induced by chronic pacing of left atrial fibrillation, the present study aimed to investigate the protein expression and content change of Notch-1 and its downstream target genes including Hes1, Jagged1, and SERCA2a in the atrial myocardium of canines with chronic AF. Furthermore, the correlation between Notch-1/Hes1/Jagged1 and the SERCA2a calcium pump was also analyzed.
methodsTen healthy Beagle dogs including both males and females, aged 7-9 years were randomly divided into a sham group (n = 5) and AF group (n = 5). The AF group underwent minimally invasive surgery with implantation of a pacemaker into the left atrial appendage for induction of AF. After 8 weeks of pacemaker implantation, animals were euthanized and specimens from the right and left atrial free walls were excised for histologic and biochemical analyses.
resultsAfter 8 weeks' pacemaker implantation, immunohistochemical expression of Notch-1, Hes1, Jagget1 and SERCA2a in the sham group was positive. Compared with the sham operation group, the intensity of Notch-1, Hes1 and Jagget1 in AF group was stronger with a significant increasing trend in the intensity of the color, respectively. The expression of SERCA2a was weak; the intensity decreased significantly (P < 0.05). Pearson correlation analysis revealed that in the AF group, Notch-1 was negatively correlated with SERCA2a (r = -0.77, P = 0.028), and was positively correlated with Hes1 and Jagged1 (r = 0.92, P = 0.014; r = 0.73, P = 0.030) proteins, respectively.
conclusionThe activation of the Notch signaling pathway was associated with a decrease in SERCA2a protein expression and contributes to the development and maintenance of electrical remodeling in AF through modulation of calcium pump function and calcium homeostasis.
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Identifiers
31933799PMC6949788W3005640691What OpenQuestion holds
Registered trials
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