Evidence map›Paper›PMID 31933795›Full record

ArticleInternational journal of clinical and experimental pathology2019

Effect of IL-6 on proliferation of human thyroid anaplastic cancer stem cells.

Rendong Zheng, Guofang Chen, Xingjia Li, Xiao Wei, Chao Liu, Michael Derwahl

Abstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  9. Obesity and Thyroid Cancer Risk: An Update.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rendong ZhengDepartment of Endocrinology and Metabolism, The Third Clinical College, Nanjing University of Chinese Medicine Nanjing, China.
Guofang ChenDepartment of Endocrinology and Metabolism, The Third Clinical College, Nanjing University of Chinese Medicine Nanjing, China.
Xingjia LiDepartment of Endocrinology and Metabolism, The Third Clinical College, Nanjing University of Chinese Medicine Nanjing, China.
Xiao WeiDepartment of Endocrinology and Metabolism, The Third Clinical College, Nanjing University of Chinese Medicine Nanjing, China.
Chao LiuDepartment of Endocrinology and Metabolism, The Third Clinical College, Nanjing University of Chinese Medicine Nanjing, China.
Michael DerwahlDivision of Endocrinology, Department of Medicine, St. Hedwig Hospital, Charite, University Medicine Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of IL-6 on the proliferation of thyroid cancer stem cells.

methodsHTh74 and HTh74R thyroid cancer stem cells were cultured. The proliferation of thyroid cancer stem cells after IL-6 treatment was assessed by the MTT method. The effect of IL-6 on colony formation was observed by colony formation experiments. The expression of OCT4, ABCG2, CD133, and EMT markers was detected by real-time quantitative PCR.

resultsIL-6 promoted the proliferation of HTh74 and HTh74R thyroid cancer stem cells and enhanced sphere formation. However, anti-IL-6 inhibited the proliferation of cancer stem cells. IL-6 promoted colony formation by HTh74 and HTh74R cells and enhanced the expression of stem cell genes OCT4 and ABCG2. The expression of EMT markers E-cadherin was significantly decreased but the expression of vimentin and Snail was increased by IL-6 treatment.

conclusionsIL-6 promoted proliferation of thyroid cancer stem cells and colony formation, and increased characteristics of thyroid cancer stem cells and EMT. The proliferative effect of thyroid cancer stem cells depends on activation of the IL6/JAK1/STAT3 pathway. These effects may contribute to the development and metastasis of thyroid cancer.

Indexed as

cancer stem cellscloneInterleukin-6proliferationthyroid cancer

Identifiers

PMID31933795
PMCPMC6949779

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.