ArticleInternational journal of clinical and experimental pathology2019
Combined identification of LncRNA CCAT1 and SOX2OT in serum as an effective screening for non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- The emerging role of long non-coding RNA SOX2-OT in cancers and non-malignant diseases.Journal of physiology and biochemistry · 2025Review
- Review
- LncRNA SOX2-OT regulates AKT/ERK and SOX2/GLI-1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases.Molecular oncology · 2021Article
- Roles of Wnt/β-Catenin Signaling Pathway Regulatory Long Non-Coding RNAs in the Pathogenesis of Non-Small Cell Lung Cancer.Cancer management and research · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong non-coding RNAs (lncRNAs) CCAT1 and SOX2OT have been shown to play important regulatory roles in cancer biology. Tumor biomarkers need to be detectable in easily accessible body fluids, should be characterized by high specificity, sufficient sensitivity, and robustness against influencing factors. The aim of this study is to evaluate the clinical significance of serum CCAT1 and SOX2OT as a biomarker in the screening of NSCLC.
resultsCCAT1 and SOX2OT were shown to be detectable in the cellular fraction of peripheral human blood, showing serum levels of CCAT1 and SOX2OT were significantly increased of cancer patients as compared to cancer-free controls. The ROC curves illustrated strong separation between the NSCLC patients and control group, with an AUC of 0.846 (95% CI 0.766-0.926; P < 0.001) for CCAT1 and 0.787 (95% CI: 0.691-0.883; P < 0.001) for SOX2OT. However, the combination of SOX2OT and CCAT1 yielded an AUC of 0.894 (95% CI: 0.825-0.963; P < 0.001), which was significantly improved as compared to CCAT1 or SOX2OT alone. Moreover, the interaction between lncRNAs and some functional proteins, such as TTF1, p63, Ck7, K-ras, EGFR, may contribute to the tumorigenesis.
conclusionOur results demonstrated that increased serum CCAT1 and SOX2OT could be used as a predictive biomarker for NSCLC screening, and that combination of CCAT1 and SOX2OT had a higher positive diagnostic efficiency of NSCLC than CCAT1 or SOX2OT alone.
Indexed as
Identifiers
31933793PMC6949749W3010743517What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.